EGFR/HER2-IN-7
EGFR/HER2-IN-7 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2-IN-7 is a EGFR/HER2 kinase and DHFR inhibitor, with IC50s of 0.18 μM (EGFR), 0.146 μM (HER2), respectively. EGFR/HER2-IN-7 shows moderate inhibition on DHFR (IC50=0.907 μM).
For research use only. We do not sell to patients.
- CAS No.: 2820126-28-9
- Formula: C19H21N3O2S
- Molecular Weight:355.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
0.18 μM (EGFR); 0.146 μM (HER2); 0.907 μM (DHFR)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
13.78 μM
Compound: 27
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Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay
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[PMID: 35964425] |
| HeLa | IC50 |
7.63 μM
Compound: 27
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Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
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[PMID: 35964425] |
| HepG2 | IC50 |
10.81 μM
Compound: 27
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Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
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[PMID: 35964425] |
| MCF7 | IC50 |
8.29 μM
Compound: 27
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
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[PMID: 35964425] |
| PC-3 | IC50 |
16.63 μM
Compound: 27
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Antiproliferative activity against human PC-3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells after 72 hrs by MTT assay
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[PMID: 35964425] |
| WI-38 | IC50 |
>100 μM
Compound: 27
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Antiproliferative activity against human WI-38 cells after 72 hrs by MTT assay
Antiproliferative activity against human WI-38 cells after 72 hrs by MTT assay
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[PMID: 35964425] |
EGFR/HER2-IN-7 (compound 27) shows remarkable broad spectrum cytotoxic potency, with an IC50 value of 10.81 μM against MCF-7 breast cancer cells[1].
EGFR/HER2-IN-7 (72 h) displays anti-breast cancer activity with an IC50 value of 8.29 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 hepatocellular carcinoma, MCF-7 breast cancer, HCT-116 colorectal carcinoma, PC-3 prostate and Hea cervical epithelioid carcinoma
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Concentration:0-1 mM
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Incubation Time:72 hours
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Result:Inhibited cancer cells growth with IC50s of 10.81 μM (HepG2), 8.29 μM (MCF-7), 13.78 μM (HCT-116), 16.63 μM (PC3), 7.63 μM (Hela), respectively.
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Cell Line:Normal healthy cell line WI-38 (fetal lung fibroblast cells)
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Concentration:0-1 mM
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Incubation Time:72 hours
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Result:Showed low cytotoxicity against healthy cells with high IC50s of >100 μM, 67.2 μM, 54.18, 89.61 μM, 36.84 μM, 49.75 μM, respectively.
Chemical Information
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CAS No. 2820126-28-9
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Molecular Weight 355.45
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Formula C19H21N3O2S
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SMILES
O=C(C1=CSC2=NC(CN3CCCCC3)=C(C4=CC=C(C)C=C4)N21)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/HER2-IN-7 Related Classifications
HY-151158 Related Classifications
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