1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. EGFR/HER2-IN-7

EGFR/HER2-IN-7 

Cat. No.: HY-151158
Handling Instructions

EGFR/HER2-IN-7 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2-IN-7 is a EGFR/HER2 kinase and DHFR inhibitor, with IC50s of 0.18 μM (EGFR), 0.146 μM (HER2), respectively. EGFR/HER2-IN-7 shows moderate inhibition on DHFR (IC50=0.907 μM).

For research use only. We do not sell to patients.

EGFR/HER2-IN-7 Chemical Structure

EGFR/HER2-IN-7 Chemical Structure

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Description

EGFR/HER2-IN-7 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2-IN-7 is a EGFR/HER2 kinase and DHFR inhibitor, with IC50s of 0.18 μM (EGFR), 0.146 μM (HER2), respectively. EGFR/HER2-IN-7 shows moderate inhibition on DHFR (IC50=0.907 μM)[1].

IC50 & Target

0.18 μM (EGFR); 0.146 μM (HER2); 0.907 μM (DHFR)[1]

In Vitro

EGFR/HER2-IN-7 (compound 27) shows remarkable broad spectrum cytotoxic potency, with an IC50 value of 10.81 μM against MCF-7 breast cancer cells[1].
EGFR/HER2-IN-7 (72 h) displays anti-breast cancer activity with an IC50 value of 8.29 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 hepatocellular carcinoma, MCF-7 breast cancer, HCT-116 colorectal carcinoma, PC-3 prostate and Hea cervical epithelioid carcinoma
Concentration: 0-1 mM
Incubation Time: 72 hours
Result: Inhibited cancer cells growth with IC50s of 10.81 μM (HepG2), 8.29 μM (MCF-7), 13.78 μM (HCT-116), 16.63 μM (PC3), 7.63 μM (Hela), respectively.

Cell Cytotoxicity Assay[1]

Cell Line: Normal healthy cell line WI-38 (fetal lung fibroblast cells)
Concentration: 0-1 mM
Incubation Time: 72 hours
Result: Showed low cytotoxicity against healthy cells with high IC50s of >100 μM, 67.2 μM, 54.18, 89.61 μM, 36.84 μM, 49.75 μM, respectively.
Molecular Weight

355.45

Formula

C19H21N3O2S

SMILES

O=C(C1=CSC2=NC(CN3CCCCC3)=C(C4=CC=C(C)C=C4)N21)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
EGFR/HER2-IN-7
Cat. No.:
HY-151158
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