EGFR-IN-167

EGFR-IN-1671 is a selective EGFR inhibitor with an IC₅₀ of 0.19 nM. EGFR-IN-167 exhibits good potency against various EGFR mutants (IC₅₀ = 0.109 nM, 0.75 nM and <0.05 nM against EGFR (L858R), EGFR (C797S) and EGFR (del19), respectively). EGFR-IN-1671 covalently engages the catalytically conserved lysine of EGFR in live mammalian cells. EGFR-IN-1671 demonstrates excellent anti-proliferative activity by inhibiting EGFR autophosphorylation. EGFR-IN-1671 can be used for the study of non-small-cell lung carcinomas (NSCLC), glioblastoma and many solid tumors.

• Data Sheet (276 KB)