EGFR WT/T790M-IN-3
EGFR WT/T790M-IN-3 is an irreversible covalent EGFRWT and EGFRT790M inhibitor with IC50s value of 28.1 and 24.6 nM. EGFR WT/T790M-IN-3 hampers tubulin polymerization through IC50 value of 5.1 μM. EGFR WT/T790M-IN-3 shows significant anti-proliferative effects on HCT116 and T47D cells, with IC50 values of 3.12 and 4.12 μM, respectively. EGFR WT/T790M-IN-3 can be used for the study of cancers such as non-small cell lung cancer, colon cancer and breast cancer.
For research use only. We do not sell to patients.
- Formula: C24H22N6O2S2
- Molecular Weight:490.60
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All EGFR Isoforms
More
Biological Activity
EGFR WT/T790M-IN-3 (Compound 7a) exhibits anti-proliferative efficacy of the scaffolds toward A431, H1975, and A549 cells, with an IC50s of 49.8, 4.64 and 3.94 μM and has no discernible cytotoxic effect against HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 490.60
-
Formula C24H22N6O2S2
-
SMILES
[H]C1=CC=C(C=C1)/C(C)=N\NC(C2=C(C3=C(SC(C(N/N=C(C4=CC=C(C=C4)[H])/C)=O)=C3N)S2)N)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR WT/T790M-IN-3 Related Classifications
HY-175292 Related Classifications
Powered by Bioz