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Enmein 

Cat. No.: HY-N5028
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Enmein is isolated from I. serra with immunosuppressive effect.

For research use only. We do not sell to patients.

Enmein Chemical Structure

Enmein Chemical Structure

CAS No. : 3776-39-4

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Description

Enmein is isolated from I. serra with immunosuppressive effect[1].

In Vitro

Enmein shows significant inhibitory effect toward K562 with an IC50 value ranging from 3.2 μg/ml to 8.2 μg/ml[2].
Enmein (3.13-25 μg/ml; 48 hours) has inhibitory effect on lymphocytes with significant difference within concentration from 6.25 μg/ml to 25 μg/ml[1].
Enmein (5.5-22 μg/ml; 48 hours) causes the percentage of S stage cells decreased from 19% to 6%, causes the percentage of G2/M stage cells to decrease from 2% to 0.4%[1].

Cell Viability Assay[1]

Cell Line: Splenic lymphocyte cells
Concentration: 3.13, 6.25, 12.5, 25 μg/ml
Incubation Time: 48 hours
Result: Exhibited an IC50 value of 17 μg/ml in splenic lymphocytes.

Cell Cycle Analysis[1]

Cell Line: Splenic lymphocyte cells
Concentration: 5.5 μg/ml, 11 μg/ml, 22 μg/ml
Incubation Time: 48 hours
Result: Caused S stage cells and G2/M stage cells decreased.
In Vivo

Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression[1].

Animal Model: Balb/c mice[1]
Dosage: 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg
Administration: Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days
Result: Had inhibitory effect on IL-2 release in blood.
Molecular Weight

362.42

Formula

C₂₀H₂₆O₆

CAS No.

3776-39-4

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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