Enmein

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Enmein is isolated from I. serra with immunosuppressive effect.

For research use only. We do not sell to patients.

Enmein Chemical Structure

CAS No. : 3776-39-4

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5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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Biological Activity
Purity & Documentation
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Description

Enmein is isolated from I. serra with immunosuppressive effect^[1].

In Vitro

Enmein shows significant inhibitory effect toward K562 with an IC₅₀ value ranging from 3.2 μg/ml to 8.2 μg/ml^[2].
Enmein (3.13-25 μg/ml; 48 hours) has inhibitory effect on lymphocytes with significant difference within concentration from 6.25 μg/ml to 25 μg/ml^[1].
Enmein (5.5-22 μg/ml; 48 hours) causes the percentage of S stage cells decreased from 19% to 6%, causes the percentage of G2/M stage cells to decrease from 2% to 0.4%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Splenic lymphocyte cells
Concentration:	3.13, 6.25, 12.5, 25 μg/ml
Incubation Time:	48 hours
Result:	Exhibited an IC⁵⁰ value of 17 μg/ml in splenic lymphocytes.

Cell Cycle Analysis^[1]

Cell Line:	Splenic lymphocyte cells
Concentration:	5.5 μg/ml, 11 μg/ml, 22 μg/ml
Incubation Time:	48 hours
Result:	Caused S stage cells and G2/M stage cells decreased.

In Vivo

Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c mice^[1]
Dosage:	6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg
Administration:	Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days
Result:	Had inhibitory effect on IL-2 release in blood.

Molecular Weight

362.42

Formula

C₂₀H₂₆O₆

CAS No.

3776-39-4

SMILES

CC1([C@]2([H])[C@]3(CO[C@H]2O)[C@@]4([H])[C@@](C5=O)(C(O[C@@]3([H])C[C@@H]1O)=O)C[C@@](C5=C)([H])CC4)C

Structure Classification

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Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Distinct immunosuppressive effect by Isodon serra extracts. Int Immunopharmacol. 2005 Dec;5(13-14):1957-65. Epub 2005 Jul 13. [Content Brief]

[2]. Jiang B, et al. Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata. Planta Med. 2002 Oct;68(10):921-5. [Content Brief]

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enmein3776-39-4OthersInhibitorinhibitorinhibit

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