Edrecolomab
Based on 1 Customer Validation
Edrecolomab (Panorex) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, expressed on epithelial tissues and on various carcinomas. Edrecolomab shows anti-tumor activity and can be used in colorectal carcinoma research.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 156586-89-9
- Molecular Weight:144.18 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Mouse IgG2a kappa
Human
EpCAM/TROP1/CD326
Edrecolomab (0-100 μg/mL; 20 h) shows moderate antibody-dependent cellular cytotoxicity (ADCC)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KATO III cells
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Concentration:0-100 μg/mL
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Incubation Time:20 hours
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Result:Exhibited an ED50 value>100 ng/ml.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male nu/nu mice injected with HT-29 colon carcinoma cells[1]
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Dosage:30 μg/dose
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Administration:Intravenous injection; 30 μg/dose; day 1, 4 and 7 after tumor-cell inoculation
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Result:Inhibited tumor growth with a number of significant readings (p≤0.05).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG2a-kappa
ELISA, FACS, Functional assay
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Flow cytometric analysis of 1.5×106 HT-29 cells with Edrecolomab (HY-P99231, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Mouse IgG2a kappa Isotype Control (HY-P99978, blue) was used as the isotype control. -
Immobilized PHA111 Human EpCAM/TROP1/CD326, His Tag can bind Edrecolomab. The EC50 for this effect is 94.02 ng/mL.
Chemical Information
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CAS No. 156586-89-9
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Appearance Liquid
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Molecular Weight 144.18 kDa
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Color Colorless to light yellow
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SMILES
[Edrecolomab]
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Synonyms
Panorex; CO17-1A
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Naundorf S, et al. In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment. Int J Cancer. 2002 Jul 1;100(1):101-10. [Content Brief]
[2]. Punt CJ, et al. Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study. Lancet. 2002 Aug 31;360(9334):671-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)