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Referencia número: HY-W008927

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Fluoxastrobin

Fluoxastrobin is a fungicide. By binding to NAD-dependent epimerase/dehydratase, Fluoxastrobin interferes with electron transport, reduces ATP production and inhibits mycelial growth, thereby effectively controlling foliar diseases of tea plants. Fluoxastrobin induces oxidative stress by increasing ROS levels and lipid peroxidation, causes DNA damage and promotes apoptosis; meanwhile, it shows high acute toxicity to Danio rerio embryos and larvae. Fluoxastrobin can be used in research related to tea foliar diseases (including tea red leaf spot and tea gray leaf spot).

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No. CAS: 361377-29-9
Fòrmula: C₂₁H₁₆ClFN₄O₅
Peso molecular:458.83

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fluoxastrobin Chemical Structure

No. CAS: 361377-29-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vivo
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

In Vitro

Fluoxastrobin (13.64 μg/mL) inhibits Pestalotiopsis trachicarpicola hyphal growth with an in vitro half-maximal effective concentration of 13.64 μg/mL, disrupts fungal energy metabolism via dose-dependent inhibition of ATP production and elevation of hyphal membrane potential, and binds stably to the fungal NAD-dependent epimerase/dehydratase^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fluoxastrobin (0.03-1.0 mg/L; aqueous immersion; static, daily semi-static refresh; 72-144 hours) exhibits high acute toxicity to Danio rerio embryos (96 h LC₅₀ = 0.549 mg/L) and induces dose-dependent delayed hatching, teratogenicity, developmental impairment, oxidative stress, and DNA damage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

No. CAS 361377-29-9
Peso molecular 458.83
Fòrmula C₂₁H₁₆ClFN₄O₅
SMILES

C(=N\OC)(\C1=C(OC=2C(F)=C(OC3=C(Cl)C=CC=C3)N=CN2)C=CC=C1)/C4=NOCCO4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhang C, et al. Fluoxastrobin-induced effects on acute toxicity, development toxicity, oxidative stress, and DNA damage in Danio rerio embryos. Sci Total Environ. 2020;715:137069. [Content Brief]

[2]. Rehman AU, et al. NAD-Dependent Epimerase/Dehydratase Serves as a Novel Potential Target for Fluoxastrobin in Pestalotiopsis trachicarpicola, the Causal Agent of Tea Foliar Disease. Phytopathology®. 2025 Jul 14;115(7):794-808.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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