HILPDA - hypoxia inducible lipid droplet associated Gene

Also Known as HIG2; HIG-2; C7orf68

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29923

About HILPDA

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,455,878-128,458,418 (from NCBI)

This gene has 4 transcripts (splice variants) and 43 orthologues. Broad expression in esophagus (RPKM 37.4), fat (RPKM 20.9) and 20 other tissues.

Summary

Enables signaling receptor binding activity. Involved in several processes, including autocrine signaling; cellular response to hypoxia; and positive regulation of lipid storage. Located in several cellular components, including cell surface; lipid droplet; and secretory granule. [provided by Alliance of Genome Resources, Apr 2022]

HILPDA Products (2)

mRNA Protein Name
NM_001098786.2 NP_001092256.1 hypoxia-inducible lipid droplet-associated protein
NM_013332.4 NP_037464.1 hypoxia-inducible lipid droplet-associated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
15930302 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
15930302 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in autocrine signaling IDA
IDA: Inferred from direct assay
15930302 GOA
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
10690527 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15930302 GOA
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
20624928 GOA
involved in positive regulation of lipid storage IDA
IDA: Inferred from direct assay
20624928 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in cell surface IDA
IDA: Inferred from direct assay
15930302 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
15930302 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
20624928 GOA
located in secretory granule IDA
IDA: Inferred from direct assay
15930302 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HILPDA Protein Structure

HILPDA

HILPDA: Hypoxia-inducible lipid droplet-associated (1 - 63)

  • 0
  • 63 a.a.
Protein Preferred Names Protein Names

hypoxia-inducible lipid droplet-associated protein

  • hypoxia inducible gene 2

HILPDA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
HILPDA Q9Y5L2 GET3 Homo sapiens O43681
Validated Y2H
25416956
Intra
HILPDA Q9Y5L2 GET3 Homo sapiens O43681
Y2H Array
25416956
Intra
HILPDA Q9Y5L2 GET3 Homo sapiens O43681
Y2H Prey Pooling
25416956
Intra
HILPDA Q9Y5L2 FZD10 Homo sapiens Q9ULW2
Anti Bait CoIP
15930302
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS06174 HILPDA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19511 Hilpda Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26005 Hilpda Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HILPDA VGNC VGNC:73451
Rattus norvegicus HILPDA RGD RGD:2319900
Mus musculus HILPDA MGD MGI:1916823
Others HILPDA NCBI