Glochidiol
Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity.
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- No. CAS: 6610-56-6
- Fòrmula: C30H50O2
- Peso molecular:442.72
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
IC50: 2.76 μΜ (tubulin polymerization)[1]
In Vitro
Glochidiol (1-8 μM; 48 h) shows potent antiproliferative activity against lung cancer cell lines in a concentration-dependent manner[1].
Glochidiol interacts with tubulin by targeting the colchicine binding site[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6
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Concentration:1, 2, 4 and 8 μM
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Incubation Time:48 h
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Result:Showed potent antiproliferative activity against lung cancer cell lines NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6 with IC50 values of 4.12 µM, 2.01 µM, 7.53 µM, 1.62 µM, 4.79 µM, 7.69 µM, 2.36 µM, 6.07 µM and 2.10 µM, respectively.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice bearing HCC-44 xenografts[1]
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Dosage:60 mg/kg/day
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Administration:Intragastric administration for a period of 21 days
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Result:Decreased average tumor weight and relative tumor volume with no obvious cytotoxic effect on the major organs, including heart, liver, and kidney.
Chemical Information
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No. CAS 6610-56-6
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Peso molecular 442.72
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Fòrmula C30H50O2
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SMILES
C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]4(C)[C@]3([H])[C@@H](CC4)C(C)=C)C)([H])[C@@]5([C@@](C(C)([C@H](O)C[C@H]5O)C)([H])CC1)C
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glochidiol Related Classifications
HY-N3950 Related Classifications
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