Lonaprisan
Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect.
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- No. CAS: 211254-73-8
- Fòrmula: C28H29F5O3
- Peso molecular:508.52
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-13071
NestoronProgesterone Receptor Agonist -
HY-15606
TanaprogetProgesterone Receptor Agonist -
HY-119433
Asoprisnil -
HY-16508
Ulipristal acetateSelective Progesterone Receptor Modulator -
HY-B0257A
DydrogesteroneProgestogen -
HY-111614
Melengestrol acetateContraceptive Agent -
HY-109568
LynestrenolPXR Agonist -
HY-14959
UlipristalSelective Progesterone Receptor Modulator -
HY-131547
Org OD 02-0mPRα/PAQR7 Agonist -
HY-B1089
Ethynodiol diacetateProgesterone Receptor Agonist -
HY-11028
PF-02413873Progesterone Receptor Antagonist -
HY-111614R
Melengestrol acetate (Standard)
Actividad biológica
Descripciòn
IC50 & Target
IC50: 3.6 pM (progesterone receptor A), 2.5 pM (progesterone receptor B)
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| CV-1 | IC50 |
54 nM
Compound: ZK-230211
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In vitro antagonist potency in transactivation assay in CV-1 cells expressing androgen receptor
In vitro antagonist potency in transactivation assay in CV-1 cells expressing androgen receptor
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[PMID: 11150172] |
| NIH3T3 | IC50 |
16 nM
Compound: ZK-230211
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In vitro antagonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptor
In vitro antagonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptor
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[PMID: 11150172] |
Chemical Information
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No. CAS 211254-73-8
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Peso molecular 508.52
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Fòrmula C28H29F5O3
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SMILES
O=C1CCC2=C3[C@@H](C4=CC=C(C(C)=O)C=C4)C[C@@]5(C)[C@](CC[C@@]5(O)C(F)(C(F)(F)F)F)([H])[C@]3([H])CCC2=C1
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Synonyms
ZK 230211; BAY86 5044
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lonaprisan Related Classifications
HY-16290 Related Classifications
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