MAP3K14-IN-1
MAP3K14-IN-1 (Compound 173) is a MAP3K14 (NIK kinase) inhibitor with an IC50 of 1.8 nM. MAP3K14-IN-1 inhibits the autophosphorylation of MAP3K14 kinase. MAP3K14-IN-1 reduces the level of phosphorylated IKKα in cancer cells. MAP3K14-IN-1 inhibits the proliferation of multiple myeloma cells. MAP3K14-IN-1 can be used in research related to multiple myeloma.
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- No. CAS: 2113617-02-8
- Fòrmula: C29H31N7O2
- Peso molecular:509.61
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
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NIK/MAP3K14 1.8 nM (IC50) |
IKKα 1.3 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| JJN-3 | IC50 |
29 nM
Compound: 173
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Antiproliferative activity against human JJN-3 cells after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human JJN-3 cells after 96 hrs by CellTiter-Glo luminescence assay
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[PMID: 28947934] |
| KMS-12-BM | IC50 |
>10 μM
Compound: 173
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Antiproliferative activity against human KMS-12-BM cells after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human KMS-12-BM cells after 96 hrs by CellTiter-Glo luminescence assay
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[PMID: 28947934] |
MAP3K14-IN-1 inhibits autophosphorylation of recombinant MAP3K14/NIK kinase in cell-free assays, with an IC50 of 1.8 nM[1].
MAP3K14-IN-1 inhibits the level of p-IKKα in L363 multiple myeloma cells, with an IC50 of 1.3 nM[1].
MAP3K14-IN-1 inhibits the proliferation of JJN-3 multiple myeloma cells with an IC50 of 29 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2113617-02-8
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Peso molecular 509.61
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Fòrmula C29H31N7O2
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SMILES
C(O)[C@]1(C)C=2C(=C(C#N)C=C(C2)C3=NC(NC4=CC(C#N)=C(CCN5CCOCC5)C=C4C)=NC=C3)NC1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAP3K14-IN-1 Related Classifications
HY-124865 Related Classifications
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