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Referencia número: HY-101761A

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TM5441 sodium

10 Cited Publications

Revisión del cliente

Based on 10 publication(s) in Google Scholar

TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC₅₀ values between 13.9 and 51.1 μM. TM5441 induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence.

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No. CAS: 2319722-53-5
Fòrmula: C₂₁H₁₆ClN₂NaO₆
Peso molecular:450.80

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

TM5441 sodium Chemical Structure

No. CAS: 2319722-53-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Chemical Information

No. CAS 2319722-53-5
Peso molecular 450.80
Fòrmula C₂₁H₁₆ClN₂NaO₆
SMILES

ClC1=CC=C(NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)C(C(O[Na])=O)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (10)

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Kidney Int

Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi. [Abstract]

2023 Sep;104(3):508-525. PMID: 37356621

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Kidney Int. 2023 Sep;104(3):508-525. [Abstract]

TM5441 decreased SERPINE1, TGFB1 and CDH6.

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Kidney Int. 2023 Sep;104(3):508-525. [Abstract]

TM5441 (PAI-1 inhibitor) or vehicle (DMSO) to the previous transwell systems. TM5441 treatment in the podocytes decreased TGFB1 and FN1.
Sci Adv

Determining sex differences in aortic valve myofibroblast responses to drug combinations identified using a digital medicine platform. [Abstract]

2025 Jun 6;11(23):eadu2695. PMID: 40479052

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Jun 6;11(23):eadu2695. [Abstract]

Percent αSMA reduction in male VICs (blue) and female VICs (red) cultured on TCPS with indicated doses of TM5441 (0-1000 μM).
Eur J Pharmacol

Carbon monoxide attenuates cellular senescence-mediated pulmonary fibrosis via modulating p53/PAI-1 pathway. [Abstract]

2024 Jul 26:176843. PMID: 39068977
Eur J Pharm Sci

Metabolic activation of TM5441 in vitro and in vivo: Formation of reactive metabolites and human enzymes involved. [Abstract]

2020 Feb 15;143:105195. PMID: 31852629
Sci Rep

Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult. [Abstract]

2023 Sep 27;13(1):16210. PMID: 37758806

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Sci Rep. 2023 Sep 27;13(1):16210. [Abstract]

Paracrine senescence effects were largely abolished by the addition of the Serpin E1 inhibitor TM5441 (10 μM, pre-incubate for 1 hour) to the conditioned medium.
Biol Pharm Bull

Arid5a/IL-6/PAI-1 Signaling Is Involved in the Pathogenesis of Lipopolysaccharide-Induced Kidney Injury. [Abstract]

2023 Oct 10;46(12):1753-1760. PMID: 38044094
bioRxiv

2025 May 12.
bioRxiv

2024 October 03.
bioRxiv

2023 Nov 26.
Res Sq

Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis. [Abstract]

2023 Jun 5:rs.3.rs-2986934. PMID: 37333081

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Res Sq. 2023 Jun 5:rs.3.rs-2986934. [Abstract]

HEK293 cells with NC or ALDH1L2 siRNA were treated with PAI-1 inhibitor TM5441 and then subjected to TGF-b1 treatment.

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Placencio VR, et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10(7):e0133786. [Content Brief]

[2]. Jeong BY, et al. Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model. PLoS One. 2016 Jun 3;11(6):e0157012. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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TM5441 sodium

10 Cited Publications

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Actividad biológica
- Descripciòn
Chemical Information
Publications (10)
Pureza y Documentación
Referencias

1/16
1/16

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Jun 6;11(23):eadu2695. [Abstract]

Customer Validation
Percent αSMA reduction in male VICs (blue) and female VICs (red) cultured on TCPS with indicated doses of TM5441 (0-1000 μM).
1/16

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Kidney Int. 2023 Sep;104(3):508-525. [Abstract]

Customer Validation
TM5441 decreased SERPINE1, TGFB1 and CDH6.
1/16

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Kidney Int. 2023 Sep;104(3):508-525. [Abstract]

Customer Validation
TM5441 (PAI-1 inhibitor) or vehicle (DMSO) to the previous transwell systems. TM5441 treatment in the podocytes decreased TGFB1 and FN1.
1/16

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Sci Rep. 2023 Sep 27;13(1):16210. [Abstract]

Customer Validation
Paracrine senescence effects were largely abolished by the addition of the Serpin E1 inhibitor TM5441 (10 μM, pre-incubate for 1 hour) to the conditioned medium.
1/16

TM5441 sodium purchased from MedChemExpress. Usage Cited in: Res Sq. 2023 Jun 5:rs.3.rs-2986934. [Abstract]

Customer Validation
HEK293 cells with NC or ALDH1L2 siRNA were treated with PAI-1 inhibitor TM5441 and then subjected to TGF-b1 treatment.

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TM5441 sodium

Publications Citing Use of MedChemExpress (MCE) TM5441 sodium

Actividad biológica

Chemical Information

Publications (10)

Pureza y Documentación

Referencias

Calculators

Help & FAQs

TM5441 sodium Related Classifications

HY-101761A Related Classifications