Estradiol disulfate
Estradiol disulfate is an estradiol disulfate ester, belonging to sulfated steroid derivatives. Estradiol disulfate is a kynurenine transaminase inhibitor that acts by competing with pyridoxal phosphate for the binding site on the apoenzyme. Estradiol disulfate protects kynurenine apo-transaminase from inactivation associated with incubation. Estradiol disulfate can be used for research on kynurenine transaminase-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 3233-70-3
- Formula: C18H24O8S2
- Molecular Weight:432.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Estradiol disulfate (30 min) effectively inhibits rat kidney kynurenine aminotransferase at concentrations as low as 5 × 10-7 M[1].
Estradiol disulfate (5 × 10-6 M; 1 hour pre-incubation, 24 hours dialysis) reversibly inhibits rat kidney kynurenine aminotransferase and protects the enzyme from inactivation during 1 hour of incubation at 37°[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3233-70-3
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Molecular Weight 432.50
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Formula C18H24O8S2
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SMILES
C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OS(=O)(=O)O)=CC4)(CC1)[H])[H])(CC[C@@H]2OS(=O)(=O)O)[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Estradiol disulfate Related Classifications
HY-187845 Related Classifications
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Keywords
- Estradiol disulfate
- 3233-70-3
- Aminotransferases (Transaminases)
- Drug Derivative
- rat kidney kynurenine transaminase
- anionic sulfate group
- kynurenine transaminase inhibitor
- kynurenine holotransaminase
- kynurenine apotransaminase
- pyridoxal phosphate
- reversibly inhibits
- apoenzyme
- unconjugated parent steroids
- protects the enzyme from inactivation
- Inhibitor
- inhibitor
- inhibit