FBPase-1 inhibitor-1
Based on 1 Customer Validation
FBPase-1 inhibitor-1 (Compound 1) is an allosteric FBPase-1 inhibitor with an IC50 of 3.3 μM or 3.9 μM. FBPase-1 inhibitor-1 blocks gluconeogenesis by inhibiting FBPase-1. FBPase-1 inhibitor-1 can be used for the research of type 2 diabetes (t2dm).
For research use only. We do not sell to patients.
- Purity: 98.54%
- CAS No.: 883973-99-7
- Formula: C13H7Cl3N2O3S
- Molecular Weight:377.63
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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FBPase-1 3.3 or 3.9 μM (IC50) |
FBPase-1 inhibitor-1 (10−8 to 10−3 M; duration of the enzymatic reaction) potently inhibits human FBPase-1 activity in the malachite green assay with an IC50 of 3.3 ± 0.6 μM[1].
FBPase-1 inhibitor-1 (10−8 to 10−3 M; duration of the enzymatic reaction) inhibits human FBPase-1 activity in the coupled enzyme assay with an IC50 of 3.9 ± 0.6 μM and a Ki of 1.1 ± 0.1 μM[1].
FBPase-1 inhibitor-1 (0.01-100 μM; 3 hours) blocks gluconeogenesis in H4IIE rat hepatoma cells by inhibiting FBPase-1, reducing glucose output with an IC50 of 6.6 ± 1.6 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 883973-99-7
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Appearance Solid
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Molecular Weight 377.63
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Formula C13H7Cl3N2O3S
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Color White to off-white
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SMILES
O=S(C1=CC(Cl)=CC=C1Cl)(NC2=NC3=CC(Cl)=CC=C3O2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (331.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6481 mL | 13.2405 mL | 26.4809 mL | 66.2024 mL |
| 5 mM | 0.5296 mL | 2.6481 mL | 5.2962 mL | 13.2405 mL | |
| 10 mM | 0.2648 mL | 1.3240 mL | 2.6481 mL | 6.6202 mL | |
| 15 mM | 0.1765 mL | 0.8827 mL | 1.7654 mL | 4.4135 mL | |
| 20 mM | 0.1324 mL | 0.6620 mL | 1.3240 mL | 3.3101 mL | |
| 25 mM | 0.1059 mL | 0.5296 mL | 1.0592 mL | 2.6481 mL | |
| 30 mM | 0.0883 mL | 0.4413 mL | 0.8827 mL | 2.2067 mL | |
| 40 mM | 0.0662 mL | 0.3310 mL | 0.6620 mL | 1.6551 mL | |
| 50 mM | 0.0530 mL | 0.2648 mL | 0.5296 mL | 1.3240 mL | |
| 60 mM | 0.0441 mL | 0.2207 mL | 0.4413 mL | 1.1034 mL | |
| 80 mM | 0.0331 mL | 0.1655 mL | 0.3310 mL | 0.8275 mL | |
| 100 mM | 0.0265 mL | 0.1324 mL | 0.2648 mL | 0.6620 mL |
FBPase-1 inhibitor-1 Related Classifications
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