Ferric pyrophosphate
Based on 1 Customer Validation
Ferric pyrophosphate is an orally effective anti-inflammatory agent and iron fortifier. Ferric pyrophosphate downregulates the expression of colonic pro-inflammatory cytokines, modulates the intestinal flora, and corrects the dysbiosis associated with iron deficiency anemia (IDA). Ferric pyrophosphate can be used in studies related to iron deficiency anemia.
For research use only. We do not sell to patients.
- CAS No.: 10058-44-3
- Formula: Fe4(P2O7)3
- Molecular Weight:745.21
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley suckling rats (mixed gender, newborn litters adjusted to 12 pups each, iron deficiency anemia induced via maternal low-iron diet during pregnancy)[1]
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Dosage:2 mg Fe/kg BW; 10 mg Fe/kg BW
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Administration:p.o.; daily; 13 days (postnatal days 2-14)
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Result:Significantly increased body weight of IDA rats compared to the IDA control group at the end of treatment.
Significantly down-regulated colonic mRNA expression of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β to levels not significantly different from the normal control group.
Reversed IDA-induced gut microbiota structural shifts (high dose), restoring the community structure to resemble the normal control group; increased the relative abundance of beneficial bacteria Bacteroides (from 6.9% to 18.7%) and Akkermansia compared to the IDA control group, and had a greater abundance of these taxa than high-dose FeSO4.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 10058-44-3
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Appearance Solid
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Molecular Weight 745.21
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Formula Fe4(P2O7)3
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Color Off-white to light yellow
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SMILES
[Fe4(P2O7)3]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 50 mg/mL (67.10 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3419 mL | 6.7095 mL | 13.4190 mL | 33.5476 mL |
| 5 mM | 0.2684 mL | 1.3419 mL | 2.6838 mL | 6.7095 mL | |
| 10 mM | 0.1342 mL | 0.6710 mL | 1.3419 mL | 3.3548 mL | |
| 15 mM | 0.0895 mL | 0.4473 mL | 0.8946 mL | 2.2365 mL | |
| 20 mM | 0.0671 mL | 0.3355 mL | 0.6710 mL | 1.6774 mL | |
| 25 mM | 0.0537 mL | 0.2684 mL | 0.5368 mL | 1.3419 mL | |
| 30 mM | 0.0447 mL | 0.2237 mL | 0.4473 mL | 1.1183 mL | |
| 40 mM | 0.0335 mL | 0.1677 mL | 0.3355 mL | 0.8387 mL | |
| 50 mM | 0.0268 mL | 0.1342 mL | 0.2684 mL | 0.6710 mL | |
| 60 mM | 0.0224 mL | 0.1118 mL | 0.2237 mL | 0.5591 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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