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Cat. No.: HY-189806

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VS-24

VS-24 is a DHODH inhibitor with anti-plant pathogenic fungi activity. VS-24 targets fungal DHODH and inhibits de novo pyrimidine biosynthesis. VS-24 inhibits the mycelial growth of plant pathogenic fungi and exhibits broad-spectrum antifungal activity against Valsa mali, Botrytis cinerea, Gaeumannomyces graminis, Magnaporthe oryzae, etc. VS-24 can be used for research on plant fungal diseases.

For research use only. We do not sell to patients.

CAS No.: 1197636-39-7
Formula: C₂₆H₂₇N₃O₃
Molecular Weight:429.51

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Please store the product under the recommended conditions in the Certificate of Analysis.

VS-24 Chemical Structure

CAS No.: 1197636-39-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

VS-24 (50 mg/L) exhibits mycelial inhibitory activity against Valsa mali, Botrytis cinerea, Gaeumannomyces graminis, and Magnaporthe oryzae, with inhibition rates of 96.0%, 76.7%, 75.3%, and 76.5%, respectively^[1].
VS-24 (50 mg/L) exhibits broad-spectrum antifungal activity against eight plant pathogenic fungi, with an EC₅₀ value of 6.05 mg/L against Valsa mali, 12.72 mg/L against Gaeumannomyces graminis, 14.82 mg/L against Botrytis cinerea, and 12.94 mg/L against Magnaporthe oryzae^[1].
VS-24 (100-200 mg/L) provides 45.1% protection against Valsa mali on apple branches at 200 mg/L and 33.3% protection at 100 mg/L^[1].
VS-24 (50 mg/L) inhibits BcDHODH by 63.0%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Filamentous Fungal Mold Culture and Sporulation

Chemical Information

CAS No. 1197636-39-7
Molecular Weight 429.51
Formula C₂₆H₂₇N₃O₃
SMILES

O=C(OC)C1=C(C2=CC=CC=C2)C3=CC=CC=C3N=C1CN4CCN(C(C5CC5)=O)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin GT, et al. Discovery of Potential Fungal Dihydroorotate Dehydrogenase Inhibitors Via Structure-based Virtual Screening for Plant Disease Control. Journal of agricultural and food chemistry. 2026 Sep 09;74(35):27416-27426.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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