Garsevil
Garsevil (LSL 60101) is a biphasic, selective imidazoline I2 receptor (I2-IR) ligand, with a pKi of 9.03 and a Ki of 0.9 nM at the high-affinity site, and a pKi of 5.25 and a Ki of 5.6 nM at the low-affinity site. Garsevil is applicable to research related to Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 150985-54-9
- Formula: C11H8N2O
- Molecular Weight:184.20
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Garsevil exhibits excellent selectivity for I2-IR over α2-adrenergic receptors (α2-AR), with an I2/α2 selectivity ratio of 7244.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 150985-54-9
-
Molecular Weight 184.20
-
Formula C11H8N2O
-
SMILES
N=1C=CNC1C=2OC=3C=CC=CC3C2
-
Synonyms
LSL 60101
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
Keywords
- Garsevil
- 150985-54-9
- LSL 60101
- LSL60101
- LSL-60101
- neuroinflammatory gene expression
- α2-adrenergic receptors
- alzheimer’s disease
- adult Sprague-Dawley rats
- human I2-IR
- imidazoline I2 receptor
- human prefrontal cortex I2-imidazoline receptors
- hippocampal FADD protein
- 5-month-old female 5xFAD mice
- adult CD-1 mice
- Inhibitor
- inhibitor
- inhibit