Garsevil
Garsevil (LSL 60101) is a biphasic, selective imidazoline I2 receptor (I2-IR) ligand, with a pKi of 9.03 and a Ki of 0.9 nM at the high-affinity site, and a pKi of 5.25 and a Ki of 5.6 nM at the low-affinity site. Garsevil is applicable to research related to Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 150985-54-9
- Formula: C11H8N2O
- Molecular Weight:184.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Garsevil exhibits excellent selectivity for I2-IR over α2-adrenergic receptors (α2-AR), with an I2/α2 selectivity ratio of 7244.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 150985-54-9
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Molecular Weight 184.20
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Formula C11H8N2O
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SMILES
N=1C=CNC1C=2OC=3C=CC=CC3C2
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Synonyms
LSL 60101
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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- Garsevil
- 150985-54-9
- LSL 60101
- LSL60101
- LSL-60101
- neuroinflammatory gene expression
- α2-adrenergic receptors
- alzheimer’s disease
- adult Sprague-Dawley rats
- human I2-IR
- imidazoline I2 receptor
- human prefrontal cortex I2-imidazoline receptors
- hippocampal FADD protein
- 5-month-old female 5xFAD mice
- adult CD-1 mice
- Inhibitor
- inhibitor
- inhibit