AXT-914
Based on 1 Customer Validation
AXT-914 is a Calcium-sensing receptor (CaSR) inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research.
For research use only. We do not sell to patients.
- Purity: 98.83%
- CAS No.: 717104-43-3
- Formula: C27H23BrN2O2
- Molecular Weight:487.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 717104-43-3
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Appearance Solid
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Molecular Weight 487.39
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Formula C27H23BrN2O2
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Color Light yellow to yellow
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SMILES
O=C1N=C(C2=C(N1CC3=CC=C(C=C3)Br)C=CC(OCC#C)=C2)C4=CC=C(C(C)C)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 100 mg/mL (205.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Brun J, et al. Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals. Antiviral Res. 2025 May;237:106123. [Content Brief]
[2]. Letz S, et al. Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing Bartter syndrome Type 5 and autosomal dominant hypocalcemia. PLoS One. 2014 Dec 15;9(12):e115178. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0517 mL | 10.2587 mL | 20.5174 mL | 51.2936 mL |
| 5 mM | 0.4103 mL | 2.0517 mL | 4.1035 mL | 10.2587 mL | |
| 10 mM | 0.2052 mL | 1.0259 mL | 2.0517 mL | 5.1294 mL | |
| 15 mM | 0.1368 mL | 0.6839 mL | 1.3678 mL | 3.4196 mL | |
| 20 mM | 0.1026 mL | 0.5129 mL | 1.0259 mL | 2.5647 mL | |
| 25 mM | 0.0821 mL | 0.4103 mL | 0.8207 mL | 2.0517 mL | |
| 30 mM | 0.0684 mL | 0.3420 mL | 0.6839 mL | 1.7098 mL | |
| 40 mM | 0.0513 mL | 0.2565 mL | 0.5129 mL | 1.2823 mL | |
| 50 mM | 0.0410 mL | 0.2052 mL | 0.4103 mL | 1.0259 mL | |
| 60 mM | 0.0342 mL | 0.1710 mL | 0.3420 mL | 0.8549 mL | |
| 80 mM | 0.0256 mL | 0.1282 mL | 0.2565 mL | 0.6412 mL | |
| 100 mM | 0.0205 mL | 0.1026 mL | 0.2052 mL | 0.5129 mL |
AXT-914 Related Classifications
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