4-Thiouridine
Based on 7 publication(s) in Google Scholar
4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response.
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- Pureza: 99.98%
- No. CAS: 13957-31-8
- Fòrmula: C9H12N2O5S
- Peso molecular:260.27
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 4-Thiouridine
More- Cancer Commun (Lond). 2024 Nov;44(11):1231-1260. [Abstract]
- Mol Cell. 2026 Feb 19;86(4):674-692.e10. [Abstract]
- Adv Sci (Weinh). 2026 Mar 12:e22572. [Abstract]
- Oncogene. 2026 Jun 19. [Abstract]
- J Virol. 2025 Sep 15:e0075025. [Abstract]
- University of Pennsylvania. 2025.
- bioRxiv. 2024 Aug 24:2024.08.23.609430. [Abstract]
Actividad biológica
Chemical Information
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No. CAS 13957-31-8
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Appearance Solid
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Peso molecular 260.27
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Fòrmula C9H12N2O5S
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Color White to yellow
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SMILES
O=C(N1)N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C=CC1=S
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (7)
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Journal Impact Factor
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Most Recent
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Cancer Commun (Lond)
Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti-PD-1 therapy in hepatocellular carcinoma. [Abstract]2024 Nov;44(11):1231-1260. PMID: 39223929 -
Mol Cell
HSPA1A and DNAJB1 regulate NELF condensate dynamics to safeguard transcriptional recovery under heat stress. [Abstract]2026 Feb 19;86(4):674-692.e10. PMID: 41653920 -
Adv Sci (Weinh)
2026 Mar 12:e22572. PMID: 41816968 -
Oncogene
The splicing factor hnRNPA1 promotes osimertinib resistance in lung adenocarcinoma by regulating NEDD4L alternative splicing. [Abstract]2026 Jun 19. PMID: 42321531 -
J Virol
Sensing of Ebinur Lake virus by distinct pattern recognition receptors dictates cell-type specific innate immunity and pathogenesis. [Abstract]2025 Sep 15:e0075025. PMID: 40952117 -
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bioRxiv
2024 Aug 24:2024.08.23.609430. PMID: 39229045
Solvente y solubilidad
H2O : ≥ 100 mg/mL (384.22 mM)
DMSO : 100 mg/mL (384.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.61 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.61 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.8422 mL | 19.2108 mL | 38.4216 mL | 96.0541 mL |
| 5 mM | 0.7684 mL | 3.8422 mL | 7.6843 mL | 19.2108 mL | |
| 10 mM | 0.3842 mL | 1.9211 mL | 3.8422 mL | 9.6054 mL | |
| 15 mM | 0.2561 mL | 1.2807 mL | 2.5614 mL | 6.4036 mL | |
| 20 mM | 0.1921 mL | 0.9605 mL | 1.9211 mL | 4.8027 mL | |
| 25 mM | 0.1537 mL | 0.7684 mL | 1.5369 mL | 3.8422 mL | |
| 30 mM | 0.1281 mL | 0.6404 mL | 1.2807 mL | 3.2018 mL | |
| 40 mM | 0.0961 mL | 0.4803 mL | 0.9605 mL | 2.4014 mL | |
| 50 mM | 0.0768 mL | 0.3842 mL | 0.7684 mL | 1.9211 mL | |
| 60 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6009 mL | |
| 80 mM | 0.0480 mL | 0.2401 mL | 0.4803 mL | 1.2007 mL | |
| 100 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9605 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
4-Thiouridine Related Classifications
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