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KF21213

KF21213 is a highly selective ligand for mapping CNS adenosine A_2A receptors. KF21213 shows a high affinity for the adenosine A_2A receptors (K_i=3.0 nM).

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No. CAS: 155271-17-3
Fòrmula: C₁₉H₂₂N₄O₃
Peso molecular:354.40

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

KF21213 Chemical Structure

No. CAS: 155271-17-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

KF21213 is a highly selective ligand for mapping CNS adenosine A_2A receptors. KF21213 shows a high affinity for the adenosine A_2A receptors (K_i=3.0 nM).

IC₅₀ & Target

Ki: 3.0 nM (A_2A receptor)^[1]

Ver todos los productos específicos de isoformas Adenosine Receptor :

In Vitro

[¹¹C]KF21213 as a PET ligand for mapping adenosine A_2A receptors in the central nervous system (CNS). KF21213 shows a high affinity for the adenosine A_2A receptors in vitro (K_i=3.0 nM) and a very low affinity for the A₁ receptors (K_i>10,000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The uptake of [¹¹C]KF21213 by the striatum gradually increases for the first 15 min and then decreases. The uptake by the cortex and cerebellum is rapidly decreased after injection. Their levels are compatible with that in the blood. Consequently, the uptake ratios of striatum to cortex and striatum to cerebellum increases up to 8.6±1.6 and 10.5±2.1 (N=4), respectively, by 60 min. The striatal activity level of [¹¹C]KF21213 is retained for the initial 5 min and then gradually decreased with time, whereas that of [¹¹C]KF18446 rapidly decreases.The cerebellar activity of the two ligands rapidly decreases.The striatum-to-cerebellum uptake ratio for [¹¹C]KF21213 gradually increases to 2.4 6 0.5 (N 5 3) by 50-60 min, whereas that for [¹¹C]KF18446 increases for the first 10 min and remains constant (1.4±0.3, N=3, at 25-35 min)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 155271-17-3
Peso molecular 354.40
Fòrmula C₁₉H₂₂N₄O₃
SMILES

O=C(N1C)N(C)C2=C(N(C)C(/C=C/C3=CC=C(OC)C(C)=C3C)=N2)C1=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang WF, et al. Carbon-11-labeled KF21213: a highly selective ligand for mapping CNS adenosine A(2A) receptors with positron emission tomography. Nucl Med Biol. 2000 Aug;27(6):541-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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