Aβ aggregation-IN-5
Aβ aggregation-IN-5 is a brain-penetrant amyloid-β aggregation inhibitor. Aβ aggregation-IN-5 inhibits Aβ aggregation/oligomerization, rescues cells from AB/ROS toxicity and reduces microglial activation/NO production. Aβ aggregation-IN-5 reduces amyloid burden, neuroinflammation, microglial activation in APP/PSEN1 mice. Aβ aggregation-IN-5 can be used for the research of Alzheimer's disease.
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- Fòrmula: C32H37NO8
- Peso molecular:563.64
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
Aβ aggregation-IN-5 (Compound P4B) (20 µM; 24-48 h) inhibits Aβ (10 µM) aggregation/oligomerization[1].
Aβ aggregation-IN-5 (10-20 µM; 24-30 h) rescues SH-SY5Y cells from Aβ- and ROS-induced toxicity[1].
Aβ aggregation-IN-5 (10 µM; 24 h) reduces microglial activation and NO production in N9 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:N9 cells
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Concentration:10 µM
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Incubation Time:24 h
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Result:Reduced Iba1 expression to basal level.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Transgenic APP/PSEN1 AD mice [B6.Cg-Tg-\r\n(APPswe,PSEN 1dE9)85Dbo/Mmjax][1]
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Dosage:5 mg/kg
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Administration:i.p.; daily; 60 days
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Result:Reduced amyloid burden in the hippocampus by ~1.3-fold and in the cortex by ~1.6-fold compared to the Alzheimer’s disease control group.
Reduced microglial activation marker Iba1 levels by ~0.8-fold in hippocampus and ~0.6-fold in cortex.
Decreased CD68 levels and colocalization of amyloid plaques with activated microglia.
Observed no significant body weight changes or microscopic pathological lesions in visceral organs.
Chemical Information
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Peso molecular 563.64
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Fòrmula C32H37NO8
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SMILES
O=C(OC1=C(C=C2C(C=CN=C2CC3=CC(OC(CCC)=O)=C(C=C3)OC(CCC)=O)=C1)OC(CCC)=O)CCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aβ aggregation-IN-5 Related Classifications
HY-180997 Related Classifications
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