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Referencia número: HY-185260

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AA76-lipid

AA76-lipid (Compound aa76) is a compound with a C-terminal arginine and histidine. AA76-lipid can be used to prepare pancreas-targeted lipid nanoparticles AH-LNP. After assembling with proteins, the increased size of AH-LNP promotes Capsule-filter-mediated selective accumulation in the pancreas and receptor-mediated endocytosis, thereby enhancing pancreas-targeting ability. AA76-lipid enables highly pancreas-selective delivery of mRNA. AA76-lipid can be used in the research of pancreatic cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₅₅H₁₀₁N₉O₆
Peso molecular:984.45

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

AA76-lipid Chemical Structure

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Sample (0.1mg)

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(In Japan)

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Actividad biológica
- Descripciòn
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Bioz

Actividad biológica

Descripciòn

In Vivo

AH-LNP (composed of AA76-lipid) (80 μg/kg; i.p.; single dose) delivers mRNA with high pancreatic selectivity in C57BL/6 mice, with over 94.7% of bioluminescence signal localized to the pancreas^[1].
AH-LNP (composed of AA76-lipid) (80 μg/kg; i.p.; single dose) delivers mRNA with high pancreatic selectivity in rats, rabbits, dogs, and pigs, with nearly 90% of bioluminescence signal localized to the pancreas^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 984.45
Fòrmula C₅₅H₁₀₁N₉O₆
SMILES

O=C(CCCCCCC/C=C\CCCCCCCC)OCCN(CCOC(CCCCCCC/C=C\CCCCCCCC)=O)CCCNC([C@H](CC1=CNC=N1)NC([C@@H](N)CCCNC(N)=N)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Lei J, et al. Pancreatic-targeted lipid nanoparticles based on organ capsule filtration. Nature. Published online February 25, 2026. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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