Anticancer agent 193
Anticancer agent 193 (compound D3-3) is an inducer of ferritinophagy, eventually triggering ferroptosis. Anticancer agent 193 induces the production of lipid ROS, and significantly promoted colorectal cancer cells to release the ferrous ion in an autophagy-dependent manner.
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- Fòrmula: C34H47ClN2O6
- Peso molecular:615.20
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Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
11.18 μM
Compound: D3-3
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay
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[PMID: 38417218] |
| HCT-116 | IC50 |
15.06 μM
Compound: D3-3
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 12 hrs by CCK-8 assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 12 hrs by CCK-8 assay
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[PMID: 38417218] |
| HCT-116 | IC50 |
5.87 μM
Compound: D3-3
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38417218] |
| HT-29 | IC50 |
6.71 μM
Compound: D3-3
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Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38417218] |
| NCM460 | IC50 |
19.04 μM
Compound: D3-3
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Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38417218] |
In Vitro
Anticancer agent 193 (D3-3; 2.5-30 μM; 12-48 h) inhibits the proliferation of HCT-116 cells for 12, 24, and 48 h and the IC50 values are 15.06 μM, 11.18 μM, and 5.87 μM, respectively[1].
Anticancer agent 193 (D3-3; 5-20 μM; 12 h) considerably increases the autophagy marker protein LC3B-II/LC3B-I ratio. And it enhances FTH1 expression, a ferritin subunit[1].
Anticancer agent 193 (D3-3; 5-20 μM; 12 h) effectively promotes the accumulation of lipid ROS[1].
Anticancer agent 193 (D3-3) remarkably increases the level of ferrous iron in HCT-116 cells in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 cells
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Concentration:2.5 μM, 5 μM, 7.5 μM,10 μM, 15 μM, 30 μM
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Incubation Time:12, 24, and 48 h
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Result:Inhibited the proliferation of human colon cancer cells.
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Cell Line:HCT-116 cells
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:12 h
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Result:Induced ferritinophagy in HCT-116 cells through the LC3-NCOA4-FTH1 axis.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c nude mice injected with HCT-116 cells[1]
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Dosage:30 mg/kg or 60 mg/kg
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Administration:i.p; daily; for 2 weeks
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Result:Inhibited tumor growth in vivo.
Chemical Information
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Peso molecular 615.20
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Fòrmula C34H47ClN2O6
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SMILES
O=C(CCCCCCCCCCCNC(C(Cl)=C)=O)OC1=C2C(C[C@H](N(C)CC3)[C@](C=C4OC)([H])[C@@]23CC4=O)=CC=C1OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 193 Related Classifications
HY-162310 Related Classifications
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