CCT373566
Based on 1 Customer Validation
CCT373566 is a potent and orally active molecular glue degrader of transcriptional repressor BCL6, with an IC50 of 2.2 nM. CCT373566 shows strong antiproliferative efficacy in vitro and reduction in tumor growth in vivo.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.61%
- No. CAS: 2378853-66-6
- Fòrmula: C26H29ClF2N6O3
- Peso molecular:547.00
-
Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HT | GI50 |
8 nM
Compound: 12a; CCT373566
|
Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
|
[PMID: 35653645] |
| KARPAS-422 | GI50 |
1.4 nM
Compound: 12a; CCT373566
|
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
|
[PMID: 35653645] |
| OCI-Ly1 | GI50 |
2.1 nM
Compound: 12a; CCT373566
|
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
|
[PMID: 35653645] |
| OCI-Ly3 | GI50 |
1900 nM
Compound: 12a; CCT373566
|
Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
|
[PMID: 35653645] |
| SUD4 | GI50 |
12.5 nM
Compound: 12a; CCT373566
|
Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
|
[PMID: 35653645] |
Chemical Information
-
No. CAS 2378853-66-6
-
Appearance Solid
-
Peso molecular 547.00
-
Fòrmula C26H29ClF2N6O3
-
Color Light yellow to yellow
-
SMILES
O=C1N(C)C2=C(C=C(NC3=NC(N4C[C@H](O)C[C@H](C)C4)=NC=C3Cl)C=C2)C5=C1OCC(F)(F)[C@H](C6CC6)N5
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 50 mg/mL (91.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
-
Ficha de datos (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8282 mL | 9.1408 mL | 18.2815 mL | 45.7038 mL |
| 5 mM | 0.3656 mL | 1.8282 mL | 3.6563 mL | 9.1408 mL | |
| 10 mM | 0.1828 mL | 0.9141 mL | 1.8282 mL | 4.5704 mL | |
| 15 mM | 0.1219 mL | 0.6094 mL | 1.2188 mL | 3.0469 mL | |
| 20 mM | 0.0914 mL | 0.4570 mL | 0.9141 mL | 2.2852 mL | |
| 25 mM | 0.0731 mL | 0.3656 mL | 0.7313 mL | 1.8282 mL | |
| 30 mM | 0.0609 mL | 0.3047 mL | 0.6094 mL | 1.5235 mL | |
| 40 mM | 0.0457 mL | 0.2285 mL | 0.4570 mL | 1.1426 mL | |
| 50 mM | 0.0366 mL | 0.1828 mL | 0.3656 mL | 0.9141 mL | |
| 60 mM | 0.0305 mL | 0.1523 mL | 0.3047 mL | 0.7617 mL | |
| 80 mM | 0.0229 mL | 0.1143 mL | 0.2285 mL | 0.5713 mL |
CCT373566 Related Classifications
HY-146185 Related Classifications
Powered by Bioz