Cholesterol-PEG 600
Based on 1 Customer Validation
Cholesterol-PEG 600 is a synthetic cholesterol derivative and also a Aβ (1-42) binder. Cholesterol-PEG 600 promotes the fibrillogenesis of Aβ (1-42). Cholesterol-PEG 600 is applicable to the research of Alzheimer's disease.
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- No. CAS: 69068-97-9
- Fòrmula: C68H110O8
- Peso molecular:1055.60
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Almacenamiento:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Cholesterol-PEG 600 (24 h; 37°C) promotes fibril formation of Aβ (1-42), binds regularly to protofibrils, and forms a smooth coating on the surface of mature double-helical Aβ (1-42) fibrils[1].
Cholesterol-PEG 600 (1 h; room temperature) binds periodically to preformed Aβ (1-42) protofibrils, but binds to preformed mature double-helical Aβ (1-42) fibers in an aperiodic, disordered manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 69068-97-9
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Appearance Oil
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Peso molecular 1055.60
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Fòrmula C68H110O8
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Color Off-white to light yellow
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SMILES
O=C(OCCOC(=O)CCCCC(=O)OC1CC2=CCC3C(CCC4(C)C(CCC34)C(C)CCCC(C)C)C2(C)CC1)CCCCC(=O)OC5CC6=CCC7C(CCC8(C)C(CCC78)C(C)CCCC(C)C)C6(C)CC5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
H2O : 60 mg/mL (56.84 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9473 mL | 4.7366 mL | 9.4733 mL | 23.6832 mL |
| 5 mM | 0.1895 mL | 0.9473 mL | 1.8947 mL | 4.7366 mL | |
| 10 mM | 0.0947 mL | 0.4737 mL | 0.9473 mL | 2.3683 mL | |
| 15 mM | 0.0632 mL | 0.3158 mL | 0.6316 mL | 1.5789 mL | |
| 20 mM | 0.0474 mL | 0.2368 mL | 0.4737 mL | 1.1842 mL | |
| 25 mM | 0.0379 mL | 0.1895 mL | 0.3789 mL | 0.9473 mL | |
| 30 mM | 0.0316 mL | 0.1579 mL | 0.3158 mL | 0.7894 mL | |
| 40 mM | 0.0237 mL | 0.1184 mL | 0.2368 mL | 0.5921 mL | |
| 50 mM | 0.0189 mL | 0.0947 mL | 0.1895 mL | 0.4737 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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