DQ-9
DQ-9 is a selective immunoproteasome β5i inhibitor (IC50=0.0019 μM). DQ-9 generates additional inhibitory substances via iron-mediated intracellular activation, and induces oxidative stress, carbon-centered free radicals and macromolecular damage through its artemisinin domain. DQ-9 induces apoptosis in leukemia and multiple myeloma cells. DQ-9 exhibits selective cytotoxicity against leukemia and multiple myeloma cells by elevating the labile iron pool. DQ-9 can be used in the research of hematological malignancies (leukemia, multiple myeloma, mantle cell lymphoma, acute myeloid leukemia).
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- No. CAS: 2803611-81-4
- Fòrmula: C33H46BNO8
- Peso molecular:595.53
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Almacenamiento:
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Chemical Information
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Actividad biológica
DQ-9 (0.2-1.0 μM; 6 h) induces the accumulation of polyubiquitinated proteins in MM.1S multiple myeloma cells[1].
DQ-9 (0.1-0.5 μM; 16 h) induces G2/M phase arrest in MM.1S multiple myeloma cells, significantly upregulates p21, and exerts a stronger effect than DQ-10 (HY-18078)[1].
DQ-9 (72 h) selectively inhibits the growth of human leukemia cell lines in the NCI-60 cell panel, and exhibits stronger potency than DQ-10 in most leukemia cell lines[1].
DQ-9 (0.1-1.0 μM; 6-16 h) potently induces apoptosis in MM.1S multiple myeloma cells and HL-60 acute myeloid leukemia cells, and its pro-apoptotic activity is stronger than that of DQ-10[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MM.1S multiple myeloma cells, HL-60 acute myeloid leukemia cells
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Concentration:0.1-1.0 μM (16 h for apoptotic markers); 0.2-1.0 μM (6 h for polyubiquitination)
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Incubation Time:6 h (polyubiquitination); 16 h (apoptotic markers)
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Result:Robust cleavage of PARP and Caspase-3 was detected in MM.1S cells treated with 0.5 μM DQ-9 for 6 h, and with 0.2 μM DQ-9 for 16 h.
In HL-60 cells, cleaved PARP and Caspase-3 were detected at 0.2 μM DQ-9 following 16 h of treatment.
DQ-10 required ≥2.5 μM to induce comparable apoptotic signaling.
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Cell Line:MM.1S multiple myeloma cells
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Concentration:0.1-0.5 μM
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Incubation Time:16 h
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Result:DQ-9 induced significant G2/M phase arrest in MM.1S cells, with more pronounced arrest than DQ-10 at matched concentrations (e.g., 27.1% G2/M at 0.2 μM DQ-9 vs 19.8% at 0.2 μM DQ-10).
Treatment also induced robust accumulation of the CDK inhibitor p21, with strong upregulation observed at 0.1 μM DQ-9.
Chemical Information
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No. CAS 2803611-81-4
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Peso molecular 595.53
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Fòrmula C33H46BNO8
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SMILES
O=C(N[C@H](B1OC(C)(C)C(C)(C)O1)CC2=COC3=CC=CC=C23)C[C@@H]4[C@H](C)[C@]5([H])CC[C@@H](C)[C@]6([H])CC[C@@](O7)(C)OO[C@]65[C@]7([H])O4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DQ-9 Related Classifications
HY-183683 Related Classifications
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- DQ-9
- 2803611-81-4
- DQ9
- DQ 9
- Proteasome
- Apoptosis
- leukemia cells
- MM.1S multiple myeloma cells
- constitutive β5c subunit
- hematologic malignancies
- acute myeloid leukemia cells
- mantle cell lymphoma
- HFF-1 fibroblast cells
- immunoproteasome β5i subunit
- HL-60 acute myeloid leukemia cells
- multiple myeloma cells
- Inhibitor
- inhibitor
- inhibit