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ED-594

ED-594 is the glucuronide form of NB-506. ED-594 is one of the major metabolites of NB-506 in rat bile, mouse liver microsomes, rat liver microsomes and human liver microsomes.

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No. CAS: 217187-87-6
Fòrmula: C₃₃H₃₀N₄O₁₆
Peso molecular:738.61

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

ED-594 Chemical Structure

No. CAS: 217187-87-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

ED-594 is the glucuronide form of NB-506. ED-594 is one of the major metabolites of NB-506 in rat bile, mouse liver microsomes, rat liver microsomes and human liver microsomes^[1].

IC₅₀ & Target^[1]

Human Endogenous Metabolite

Ver todos los productos específicos de isoformas Endogenous Metabolite :

In Vitro

ED-594 (15-30 min) is formed via glucuronidation of NB-506 in mouse, rat, and human liver microsomes with distinct apparent kinetic parameters, and no ED-594 formation occurs in dog liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 217187-87-6
Peso molecular 738.61
Fòrmula C₃₃H₃₀N₄O₁₆
SMILES

O=C1C2=C3C(N([C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)C5=C(O)C=CC=C53)=C6C(C7=CC=CC(O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=C7N6)=C2C(N1NC=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Takenaga N, et al. In vitro metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo+ ++[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506), in mice, rats, dogs, and humans. Drug Metab Dispos. 1999 Feb;27(2):213-20. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ED-594

Ver todos los productos específicos de isoformas Endogenous Metabolite