Fmoc-Trp(Boc)-OH
Based on 1 Customer Validation
Fmoc-Trp(Boc)-OH (Fmoc-L-Trp(Boc)-OH) is an amino acid derivative with protective groups. Fmoc-Trp(Boc)-OH can self-assemble into stable and pH-responsive spherical nanoparticles, which can load and release bioactive molecules, with good biocompatibility and high cell uptake rate. Fmoc-Trp(Boc)-OH can be used in research on drug delivery.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.66%
- No. CAS: 143824-78-6
- Fòrmula: C31H30N2O6
- Peso molecular:526.58
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Fmoc-Trp(Boc)-OH loaded with Doxorubicin (HY-15142A) exhibits better killing effect on glioma cells than the free drug and can enhance the anti-tumor effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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No. CAS 143824-78-6
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Appearance Solid
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Peso molecular 526.58
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Fòrmula C31H30N2O6
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Color White to off-white
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SMILES
O=C([C@@H](NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)CC4=CN(C5=CC=CC=C45)C(OC(C)(C)C)=O)O
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Synonyms
Fmoc-L-Trp(Boc)-OH
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (189.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.75 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (598 KB)
- English - EN (598 KB)
- Français - FR (598 KB)
- Deutsch - DE (598 KB)
- Norwegian - NO (598 KB)
- Español - ES (598 KB)
- Swedish - SV (598 KB)
- Italian - IT (598 KB)
- Korean - KR (598 KB)
- Portuguese - PT (598 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Dube, et al. Nanoparticles generated from a tryptophan derivative: physical characterization and anti-cancer drug delivery. Amino Acids 49 (2017): 975-993. [Content Brief]
[2]. Moreira R, et al. A high-yielding solid-phase total synthesis of daptomycin using a Fmoc SPPS stable kynurenine synthon. Org Biomol Chem. 2021 Apr 14;19(14):3144-3153. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8990 mL | 9.4952 mL | 18.9905 mL | 47.4762 mL |
| 5 mM | 0.3798 mL | 1.8990 mL | 3.7981 mL | 9.4952 mL | |
| 10 mM | 0.1899 mL | 0.9495 mL | 1.8990 mL | 4.7476 mL | |
| 15 mM | 0.1266 mL | 0.6330 mL | 1.2660 mL | 3.1651 mL | |
| 20 mM | 0.0950 mL | 0.4748 mL | 0.9495 mL | 2.3738 mL | |
| 25 mM | 0.0760 mL | 0.3798 mL | 0.7596 mL | 1.8990 mL | |
| 30 mM | 0.0633 mL | 0.3165 mL | 0.6330 mL | 1.5825 mL | |
| 40 mM | 0.0475 mL | 0.2374 mL | 0.4748 mL | 1.1869 mL | |
| 50 mM | 0.0380 mL | 0.1899 mL | 0.3798 mL | 0.9495 mL | |
| 60 mM | 0.0317 mL | 0.1583 mL | 0.3165 mL | 0.7913 mL | |
| 80 mM | 0.0237 mL | 0.1187 mL | 0.2374 mL | 0.5935 mL | |
| 100 mM | 0.0190 mL | 0.0950 mL | 0.1899 mL | 0.4748 mL |
Fmoc-Trp(Boc)-OH Related Classifications
HY-W008034 Related Classifications
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