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Fremanezumab

(Synonyms: TEV-48125; LBR-101; PF-04427429; RN-307)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Fremanezumab (TEV-48125) is a humanized lgG2 monoclonal antibody that selectively and potently binds to calcitonin gene related peptide (CGRp) (IC50 values = 7.943 nM). Fremanezumab binds to mouse CGRP with an IC50 value of 19.6 nM. Fremanezumab counteracts anti-inflammatory effects of CGRP in vitro, including CGRP-mediated inhibition of LPS (HY-D1056)-induced microglial activation. Fremanezumab selectively inhibits the activation of Aδ meningeal nociceptors by cortical spreading depression (CSD) in rats. Fremanezumab can be used for the study of inflammation and chronic migraine.

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  • Pureza: 95.00%
  • No. CAS: 1655501-53-3
  • Peso molecular:145.5 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Fremanezumab
  • Experimental Validation Results for Fremanezumab
  • Fremanezumab Chemical Structure
    Fremanezumab Chemical Structure
No. CAS: 1655501-53-3
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609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG2 kappa

  • 1/16

    Flow cytometric analysis of 1X106 A549 cells with Fremanezumab (HY-P99019, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Fremanezumab Chemical Structure
    1/16
  • Fremanezumab
  • Flow cytometric analysis of 1X106 A549 cells with Fremanezumab (HY-P99019, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).