Furosemide-d5
Based on 1 Customer Validation
Furosemide-d5 is the deuterated-labeled Furosemide (HY-B0135). Furosemide is an orally active NKCC2 inhibitor that can cross the blood-brain barrier. Furosemide inhibits NKCC1, NKCC2, KCC2, KCC3, and KCC4. Furosemide selectively antagonizes GABAA receptors containing α6 and β2/3 or β3γ2 subunits. Furosemide penetrates the blood-brain barrier and blocks renal tubular sodium-chloride reabsorption, increases urinary excretion of sodium, chloride, potassium, and calcium, and activates the renin-angiotensin-aldosterone system. Furosemide can be used in research on congestive heart failure, hypertension, and edema.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.85%
- No. CAS: 1189482-35-6
- Fòrmula: C12H6D5ClN2O5S
- Peso molecular:335.77
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
No. CAS 1189482-35-6
-
Unlabeled CAS 54-31-9
-
Appearance Solid
-
Peso molecular 335.77
-
Fòrmula C12H6D5ClN2O5S
-
Color White to off-white
-
SMILES
OC(C1=C(C=C(C(S(N)(=O)=O)=C1)Cl)NC([2H])([2H])C2=C([2H])C([2H])=C([2H])O2)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : ≥ 100 mg/mL (297.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (295 KB)
-
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9782 mL | 14.8911 mL | 29.7823 mL | 74.4557 mL |
| 5 mM | 0.5956 mL | 2.9782 mL | 5.9565 mL | 14.8911 mL | |
| 10 mM | 0.2978 mL | 1.4891 mL | 2.9782 mL | 7.4456 mL | |
| 15 mM | 0.1985 mL | 0.9927 mL | 1.9855 mL | 4.9637 mL | |
| 20 mM | 0.1489 mL | 0.7446 mL | 1.4891 mL | 3.7228 mL | |
| 25 mM | 0.1191 mL | 0.5956 mL | 1.1913 mL | 2.9782 mL | |
| 30 mM | 0.0993 mL | 0.4964 mL | 0.9927 mL | 2.4819 mL | |
| 40 mM | 0.0745 mL | 0.3723 mL | 0.7446 mL | 1.8614 mL | |
| 50 mM | 0.0596 mL | 0.2978 mL | 0.5956 mL | 1.4891 mL | |
| 60 mM | 0.0496 mL | 0.2482 mL | 0.4964 mL | 1.2409 mL | |
| 80 mM | 0.0372 mL | 0.1861 mL | 0.3723 mL | 0.9307 mL | |
| 100 mM | 0.0298 mL | 0.1489 mL | 0.2978 mL | 0.7446 mL |
Furosemide-d5 Related Classifications
HY-B0135S Related Classifications
Powered by Bioz
Keywords
- Furosemide-d5
- 1189482-35-6
- Isotope-Labeled Compounds
- GABA Receptor
- NKCC
- Gamma-aminobutyric acid Receptor
- γ-Aminobutyric acid Receptor
- Na-K-Cl cotransporter
- Na(+)-K(+)-Cl(-) cotransporter
- Na+-K+-Cl− cotransporter
- GABAA receptors
- KCC2
- KCC3
- KCC4
- NKCC1
- NKCC2
- congestive heart failure
- hepatic necrosis
- loop diuretic
- renin-angiotensin-aldosterone system
- Inhibitor
- inhibitor
- inhibit