Nrp1 - neuropilin 1 Gene

Also Known as Nrp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246331

Summary

Enables semaphorin receptor activity. Involved in negative regulation of axon extension involved in axon guidance and response to wounding. Located in cell surface; growth cone; and neuronal cell body. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nrp1 Products (1)

mRNA Protein Name
NM_145098.2 NP_659566.1 neuropilin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
9288754 RGD
enables semaphorin receptor activity IMP
IMP: Inferred from mutant phenotype
9288754 RGD
Biological Process GO Annotation Evidence Referencias Source
involved in negative regulation of axon extension involved in axon guidance IMP
IMP: Inferred from mutant phenotype
9288754 RGD
involved in positive regulation of platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26410366 RGD
involved in positive regulation of smooth muscle cell chemotaxis IMP
IMP: Inferred from mutant phenotype
26410366 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
26410366 RGD
involved in wound healing IMP
IMP: Inferred from mutant phenotype
26410366 RGD
Cellular Component GO Annotation Evidence Referencias Source
located in axon IDA
IDA: Inferred from direct assay
9288754 RGD
located in cell surface IDA
IDA: Inferred from direct assay
9288754 RGD
located in growth cone IDA
IDA: Inferred from direct assay
9288754 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
9288754 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuropilin-1

  • vascular endothelial cell growth factor 165 receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-P3449A Dazdotuftide TFA Inhibitor / Phase 3
HY-P3448 Certepetide Activator 99.80% Phase 2
Inhibitory Antibodies (2)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-P99386 Vesencumab Inhibitor 99.34% Phase 1
HY-P991329 ASP-1948 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (36)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-10799 EG00229 trifluoroacetate Antagonist 98.03% Unkown
HY-112151A EG01377 dihydrochloride Inhibitor 98.98% Unkown
HY-133034 NRP1 antagonist 1 Antagonist 99.71% Unkown
HY-112151 EG01377 Inhibitor 99.90% Unkown
HY-P1663A ATWLPPR Peptide TFA Inhibitor 99.20% Unkown
HY-P10787 tLyP-1 peptide Inhibitor 98.05% Unkown
HY-RS09579 NRP1 Human Pre-designed siRNA Set A / Unkown
HY-147762 NRP1 antagonist 2 Antagonist 99.05% Unkown
HY-P10097 Flt2-11 Inhibitor 99.71% Unkown
HY-182700 NRPa-308 Inhibitor 98.96% Unkown
HY-P11286 A7RC 99.87% Unkown
HY-P11647A RPARPAR acetate Ligand 99.47% Unkown
HY-RS16529 Nrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P3449 Dazdotuftide Inhibitor / Unkown
HY-163062 Tubulin/NRP1-IN-1 / Unkown
HY-179350 EG01449 Free acid Inhibitor / Unkown
HY-179350A EG01449 Inhibitor / Unkown
HY-18333 EG00229 Inhibitor / Unkown
HY-184566A DPPE-PEG2000-iRGD / Unkown
HY-184567A DSG-PEG2000-iRGD / Unkown
HY-184576 DOPE-PEG1000-iRGD / Unkown
HY-184576A DOPE-PEG2000-iRGD / Unkown
HY-184576B DOPE-PEG3400-iRGD / Unkown
HY-184576C DOPE-PEG5000-iRGD / Unkown
HY-184577 DMG-PEG1000-iRGD / Unkown
HY-184577A DMG-PEG2000-iRGD / Unkown
HY-184577B DMG-PEG3400-iRGD / Unkown
HY-184577C DMG-PEG5000-iRGD / Unkown
HY-NP223 PLGF-2 Protein, human / Unkown
HY-P10788 CK3 peptide Inhibitor / Unkown
HY-P11647 RPARPAR Ligand / Unkown
HY-RS09204 NELL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128446 CAY10781 Inhibitor 98.04% Unkown
HY-P3448S Certepetide-13C6,15N2 Activator / Unkown
HY-P3448S1 Certepetide-13C2,15N Activator / Unkown
HY-RS22960 Nrp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nrp1 NCBI NCBI:8829