GR231118 TFA
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8).
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- Fòrmula: C112H171F3N34O26
- Peso molecular:2466.76
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Neuropeptide Y Receptor
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Actividad biológica
Chemical Information
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Peso molecular 2466.76
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Fòrmula C112H171F3N34O26
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Synonyms
1229U91 TFA; GW1229 TFA
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Sequence Shortening
Sequence 1:IEP-{Dpr}-YRLRY-NH2;Sequence 1':IEP-{Dpr}-YRLRY-NH2 (Amide bridge:Glu2-Dpr4';Dpr4-Glu2')
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol [Content Brief]
[2]. Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GR231118 TFA Related Classifications
HY-P1321A Related Classifications
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