country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-122757

Copy Link Print Information

Hydrazinocurcumin

(Synonyms: Curcumin pyrazole)

Hydrazinocurcumin (Curcumin pyrazole) is a potent endothelial cell proliferation inhibitor (IC₅₀=520 nM). Hydrazinocurcumin disrupts angiogenic signaling pathways and inhibits endothelial cell migration and tube formation, exerting anti-angiogenic activity. Hydrazinocurcumin is promising for research of tumor angiogenesis inhibition, metastatic cancer, and vascular-dependent diseases such as retinopathies.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 131068-23-0
Fòrmula: C₂₁H₂₀N₂O₄
Peso molecular:364.39

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Hydrazinocurcumin Chemical Structure

No. CAS: 131068-23-0

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	19.4 μM Compound: 1	Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymography Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymography	[PMID: 19128977]
Ehrlich	ED₅₀	100 mM Compound: 10	Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay	10.1007/s00044-009-9199-3
HaCaT	IC₅₀	16.2 μM Compound: 5	Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay	[PMID: 24920381]
LNCaP	IC₅₀	>50 μM Compound: 5	Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24920381]
LNCaP	IC₅₀	3.4 μM Compound: 12	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 19249204]
MCF-10A	IC₅₀	>50 μM Compound: 12	Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay	[PMID: 19249204]
MCF7	IC₅₀	4.19 μM Compound: 12	Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay	[PMID: 19019687]
MCF7	IC₅₀	5.9 μM Compound: 12	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 19249204]
MDA-MB-231	IC₅₀	6.6 μM Compound: 12	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 19249204]
PBMC	IC₅₀	>50 μM Compound: 5	Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay	[PMID: 24920381]
PC-3	IC₅₀	5.6 μM Compound: 12	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 19249204]
SK-BR-3	IC₅₀	0.258 μM Compound: 12	Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay	[PMID: 19019687]

Chemical Information

No. CAS 131068-23-0
Peso molecular 364.39
Fòrmula C₂₁H₂₀N₂O₄
SMILES

OC1=CC=C(/C=C/C2=NNC(/C=C/C3=CC=C(O)C(OC)=C3)=C2)C=C1OC
Synonyms

Curcumin pyrazole
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Shim JS, et al. Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation. Bioorg Med Chem. 2002 Sep;10(9):2987-92. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto