Kentsin
Kentsin (Thr-Pro-Arg-Lys), a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation, without binding to opioid receptors. Kentsin has opiate properties on gastrointestinal motility.
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- No. CAS: 56767-30-7
- Fòrmula: C21H40N8O6
- Peso molecular:500.59
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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- Referencias
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Actividad biológica
Descripciòn
In Vitro
Kentsin (100 μg/mL, 18 h) increases endogenous xenotropic virus expression in K-Balb 19a/h cells transformed with Kirsten sarcoma virus[2].
Kentsin (30 μM) does not inhibit electrically stimulated contractions of the guinea pig ileum (GPI) or mouse vas deferens (MVD)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Kentsin (20 and 100 ng/kg, i.c.v.) inhibits the antral motility index and disrupts the jejunal migrating motor complex in fasted dogs[3].
Kentsin (4.0 μg/kg, i.c.v. 2 hours after the beginning of a meal) restores the "fasted” (the migrating myoelectric complex of intestinal motility), and can be blocked by previous Naloxone (400 μg/kg, i.c.v.)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Fasted dogs[3]
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Dosage:20 and 100 ng/kg
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Administration:Intracerebroventricular injection (i.c.v.)
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Result:Inhibited the antral motility index by 51.2 and 76.1%.
Disrupted the jejunal migrating motor complex for 2 and 4 h respectively.
Chemical Information
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No. CAS 56767-30-7
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Peso molecular 500.59
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Fòrmula C21H40N8O6
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Sequence Shortening
TPRK
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Fox DA, et al. Kentsin: tetrapeptide from hamster embryos produces naloxone-sensitive effects without binding to opioid receptors. Peptides. 1987 Jul-Aug;8(4):613-8. [Content Brief]
[2]. Suk WA, et al. Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides, tuftsin and kentsin. J Gen Virol. 1981 Jan;52(Pt 1):189-94. [Content Brief]
[3]. Bueno L, et al. Central opioid-like influence of a tetrapeptide from hamster embryo (kentsin) on gastrointestinal motility in dogs. Eur J Pharmacol. 1985 Aug 7;114(1):67-70. [Content Brief]
[4]. Buéno L, et al. A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not on pain perception. Life Sci. 1986 Jul 14;39(2):141-6. [Content Brief]
[5]. Wieczorek Z, et al. The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Peptides. 1994;15(2):215-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kentsin Related Classifications
HY-123492 Related Classifications
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