KF-20444
KF-20444 is an orally active ALK inhibitor with blood-brain barrier penetration. KF-20444 exhibits strong inhibitory activity against ALK fusion proteins (EML4-ALK) and ALK resistance mutations (including L1196M, G1202R, and F1174L). KF-20444 effectively suppresses the phosphorylation of ALK in ALK-driven cancer cell lines, thereby inhibiting cancer cell proliferation and inducing apoptosis. KF-20444 demonstrates anti-tumor efficacy in mouse models bearing ALK-positive non-small cell lung cancer (NSCLC) or neuroblastoma. KF-20444 can be used for the study of ALK-driven malignancies.
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- No. CAS: 154015-73-3
- Fòrmula: C25H17F2NO2
- Peso molecular:401.40
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
Chemical Information
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No. CAS 154015-73-3
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Peso molecular 401.40
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Fòrmula C25H17F2NO2
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SMILES
O=C(C1=C2CCCC3=C(C=CC(C4=C(F)C=CC=C4)=C3)C2=NC5=C1C=C(C=C5)F)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KF-20444 Related Classifications
HY-105369 Related Classifications
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