LP23
LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC50: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.9%
- No. CAS: 3008239-25-3
- Fòrmula: C27H27N3O5S
- Peso molecular:505.59
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Immunology/Inflammation Compound Library
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Actividad biológica
IC50: 16.7 nM (PD-L1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
8.9 μM
Compound: LP23
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Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37674362] |
| B16-F10 | IC50 |
>10 μM
Compound: LP23
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Antitumor activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antitumor activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37674362] |
| HepG2 | IC50 |
4.32 μM
Compound: LP23
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Antitumor immunity against IFNgamma-stimulated human HepG2 cells expressing human PD-L1 co-cultured with PHA-stimulated human Jurkat T cells expressing human PD-1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antitumor immunity against IFNgamma-stimulated human HepG2 cells expressing human PD-L1 co-cultured with PHA-stimulated human Jurkat T cells expressing human PD-1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 37674362] |
| MCF7 | IC50 |
7.9 μM
Compound: LP23
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Antitumor activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37674362] |
Chemical Information
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No. CAS 3008239-25-3
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Appearance Solid
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Peso molecular 505.59
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Fòrmula C27H27N3O5S
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Color White to off-white
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SMILES
O=C([C@@H](NCC1=CC(CSC2=NN=C(COC3=C(C)C(C4=CC=CC=C4)=CC=C3)O2)=CC=C1)CO)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 106 mg/mL (209.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9779 mL | 9.8894 mL | 19.7789 mL | 49.4472 mL |
| 5 mM | 0.3956 mL | 1.9779 mL | 3.9558 mL | 9.8894 mL | |
| 10 mM | 0.1978 mL | 0.9889 mL | 1.9779 mL | 4.9447 mL | |
| 15 mM | 0.1319 mL | 0.6593 mL | 1.3186 mL | 3.2965 mL | |
| 20 mM | 0.0989 mL | 0.4945 mL | 0.9889 mL | 2.4724 mL | |
| 25 mM | 0.0791 mL | 0.3956 mL | 0.7912 mL | 1.9779 mL | |
| 30 mM | 0.0659 mL | 0.3296 mL | 0.6593 mL | 1.6482 mL | |
| 40 mM | 0.0494 mL | 0.2472 mL | 0.4945 mL | 1.2362 mL | |
| 50 mM | 0.0396 mL | 0.1978 mL | 0.3956 mL | 0.9889 mL | |
| 60 mM | 0.0330 mL | 0.1648 mL | 0.3296 mL | 0.8241 mL | |
| 80 mM | 0.0247 mL | 0.1236 mL | 0.2472 mL | 0.6181 mL | |
| 100 mM | 0.0198 mL | 0.0989 mL | 0.1978 mL | 0.4945 mL |
LP23 Related Classifications
HY-156085 Related Classifications
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