LY3104607
LY3104607 is a potent and selective G protein-coupled receptor 40 (GPR40) agonist. LY3104607 can be used in research of diabetes.
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- No. CAS: 1795232-22-2
- Fòrmula: C27H25N3O3
- Peso molecular:439.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
108 nM
Compound: 4; LY3104607
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Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay
Agonist activity at human PK-tagged GPR40 expressed in HEK293 cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 % heat inactivated FBS by beta-galactosidase reporter gene assay
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[PMID: 29236497] |
| HEK293 | EC50 |
11 nM
Compound: 4; LY3104607
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Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay
Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 mins by calcium 4 dye-based FLIPR assay
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[PMID: 29236497] |
| HEK293 | EC50 |
119 nM
Compound: 6
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Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay
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[PMID: 27825762] |
Chemical Information
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No. CAS 1795232-22-2
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Peso molecular 439.51
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Fòrmula C27H25N3O3
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SMILES
CC(C=CC=C1C)=C1C2=NN3C(C=CC(COC4=CC=C([C@@H](C#CC)CC(O)=O)C=C4)=C3)=N2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY3104607 Related Classifications
HY-111116 Related Classifications
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