LY3202626
LY3202626 is a CNS penetrant BACE inhibitor with IC50s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1628690-73-2
- Fòrmula: C22H20F2N8O2S
- Peso molecular:498.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
IC50: 0.615 nM (BACE1), 0.871 nM (BACE2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.615 nM
Compound: 7; LY-3202626
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Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells after 16 to 24 hrs by FRET assay
Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells after 16 to 24 hrs by FRET assay
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[PMID: 30709653] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1628690-73-2
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Peso molecular 498.51
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Fòrmula C22H20F2N8O2S
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SMILES
O=C(NC1=CC=C(C([C@@]23N=C(SC[C@@]2(CN(C3)C4=NC=C(C=N4)F)[H])N)=C1)F)C5=NC=C(N=C5)OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY3202626 Related Classifications
HY-118098 Related Classifications
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