ML416
ML416 is a broad-spectrum antiviral agent. ML416 inhibits host de novo pyrimidine biosynthesis, and induces a variety of interferon-stimulated genes (ISGs). ML416 can be used for the research of viral infections including alphaviruses, influenza virus, and HIV-1.
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- No. CAS: 2043014-84-0
- Fòrmula: C14H15FN2OS2
- Peso molecular:310.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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HIV-1 |
ML416 (Compound 1) (10 μM; 24 h) potently inhibits HIV-1 infectivity in TZM-bl cells, achieving 94% inhibition at a 10 μM concentration[1].
ML416 (1 μM; 2 h pretreatment + 18 h post-infection incubation) potently inhibits V3526-luc and pVSV-luc replication in HEK 293T cells, and its antiviral activity is reversed by exogenous pyrimidines (cytidine, uridine), confirming its mechanism of action involves inhibition of pyrimidine biosynthesis[1].
ML416 (48-96 h) shows low cytotoxicity against Vero 76 cells, with CC50 values ranging from 31.0 to 74.1 μM across 48 to 96 hours of exposure[1].
ML416 (5 μM; 8 h pre-treatment) reduces progeny virus titers by 1.3 to 4.768 log at 5 μM in Vero 76 cells across a broad range of viruses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2043014-84-0
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Peso molecular 310.41
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Fòrmula C14H15FN2OS2
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SMILES
O=C(N(C1=NC2=C(S1)CCCC2)C)CC=3SC=CC3F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Chung DH, et al. Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State. Antimicrob Agents Chemother. 2016;60(8):4552-4562. Published 2016 Jul 22. [Content Brief]
[2]. Jennifer E. Golden, et al. Inhibitors of viruses. WO2016183093A1. 2017-11-11
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML416 Related Classifications
HY-125613 Related Classifications
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