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Referencia número: HY-186236

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N42FTA

N42FTA is a non-covalent, non-suicidal inhibitor of FabA from Pseudomonas aeruginosa and Escherichia coli, with IC₅₀ values of 3.27 μM and 2.31 μM, respectively. As a natural substrate mimetic, N42FTA blocks the cross-linking between acyl carrier protein and FabA in Escherichia coli. N42FTA shows no significant antibacterial activity due to poor permeability. N42FTA can be used in studies related to Pseudomonas aeruginosa and Escherichia coli infections.

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No. CAS: 892706-90-0
Fòrmula: C₁₃H₁₁ClN₄O
Peso molecular:274.71

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

N42FTA Chemical Structure

No. CAS: 892706-90-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Actividad biológica

Descripciòn

In Vitro

N42FTA inhibits Pseudomonas aeruginosa FabA in direct ultraviolet absorption assays with an IC₅₀ of 3.27 μM; it also inhibits Escherichia coli FabA with an IC₅₀ of 2.31 μM^[1].
N42FTA competitively inhibits Pseudomonas aeruginosa FabA in coupled fluorescence assays, with an IC₅₀ of 2 μM (pIC₅₀ = 5.7)^[1].
N42FTA binds to Pseudomonas aeruginosa FabA, with a binding constant of 4 μM measured by isothermal titration calorimetry^[1].
N42FTA (250 μM; 24 h) inhibits 94% of the cross-linking between E. coli FabA and acyl carrier protein, thereby blocking the formation of the native substrate-enzyme complex^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

No. CAS 892706-90-0
Peso molecular 274.71
Fòrmula C₁₃H₁₁ClN₄O
SMILES

ClC1=CC=C(CNC2=NC(C3=CC=CO3)=NN2)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Moynié L, et al.. A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA. Journal of molecular biology. 2016 Jan 16;428(1):108-120. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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