Nec-34i
Nec-34i is an inactive analog structurally similar to Nec-34 (HY-132203). Nec-34i has no effect on RIPK1 kinase activity and cannot inhibit necroptosis.
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- No. CAS: 2212541-00-7
- Fòrmula: C21H19N3O2S
- Peso molecular:377.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Nec-34i (20 μM; 1 h) does not bind to or stabilize recombinant human RIPK1 kinase domain (residues 1-330) in a protein thermal shift assay[1].
Nec-34i (20 μM; 10 min) does not inhibit the in vitro kinase activity of human RIPK1 kinase domain (residues 1-330) from transfected 293T cells[1].
Nec-34i (10 μM) does not inhibit TNFα-induced necroptosis in FADD-deficient Jurkat cells or zVAD.fmk-induced necroptosis in L929 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2212541-00-7
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Peso molecular 377.46
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Fòrmula C21H19N3O2S
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SMILES
N#CC1=C(NC(CC1C2=CC=C(C)C=C2)=O)SCC(NC3=CC=CC=C3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nec-34i Related Classifications
HY-W674387 Related Classifications
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