country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-105400

Copy Link Print Information

NIP 502

NIP 502 is a pyridazinone derivative with orally active anti-inflammation and anti-immunology effects. NIP 502 can be used for the research of asthma.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 108616-42-8
Fòrmula: C₁₄H₁₆ClN₃O₃
Peso molecular:309.75

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

NIP 502 Chemical Structure

No. CAS: 108616-42-8

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

NIP 502 is a pyridazinone derivative with orally active anti-inflammation and anti-immunology effects. NIP 502 can be used for the research of asthma^[1].

In Vitro

NIP 502 (30-300 μM, 5 mins) significantly inhibits FMLP (HY-P0224)-induced superoxide anion production by guinea pig alveolar macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NIP-502 (3-10 mg/kg, p.o., 1 h before antigen challenge) inhibits the antigen-induced immediate asthmatic response in passively sensitized guinea pigs^[1].
NIP-502 (30 mg/kg, p.o., 1 h before each ovalbumin aerosol inhalation) inhibits the Ovalbumin (HY-W250978)-induced increase in the number of macrophages, eosinophils, and neutrophils in the bronchoalveolar lavage fluid of guinea pigs^[1].
NIP-502 (30-50 mg/kg, p.o., 1 h before antigen challenge) inhibits the passive cutaneous anaphylactic reaction in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 108616-42-8
Peso molecular 309.75
Fòrmula C₁₄H₁₆ClN₃O₃
SMILES

CCOC1=C(C=CC(CNC2=C(C(NN=C2)=O)Cl)=C1)OC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yamamoto A, et al. Effects of NIP-502 on antigen-induced bronchial responses and allergic reactions in animal models. Jpn J Pharmacol. 1995 May;68(1):47-55. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto