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Orilanolimab

(Synonyms: SYNT001; ALXN1830)
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Based on 1 Customer Validation

Orilanolimab (SYNT001) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza : 99.9%
  • No. CAS: 2066544-85-0
  • Peso molecular:144.01 kDa
  • Almacenamiento:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Orilanolimab
  • Experimental Validation Results for Orilanolimab
  • Experimental Validation Results for Orilanolimab
  • Orilanolimab Chemical Structure
    Orilanolimab Chemical Structure
No. CAS: 2066544-85-0
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Orilanolimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized Human FCGRT & B2M Heterodimer Protein (His Tag) can bind Orilanolimab. The EC50 for this effect is 8.23 ng/mL.

  • 1/16

    Flow Cytometry analysis of 1.5×106 THP-1 cells with Orilanolimab (HY-P99791, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Orilanolimab Chemical Structure
    1/16
  • Orilanolimab
  • Immobilized Human FCGRT & B2M Heterodimer Protein (His Tag) can bind Orilanolimab. The EC50 for this effect is 8.23 ng/mL.
  • Flow Cytometry analysis of 1.5×106 THP-1 cells with Orilanolimab (HY-P99791, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).