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Referencia número: HY-181231

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PROTAC CDK9 degrader-12

PROTAC CDK9 degrader-12 is a selective CDK9 PROTAC degrader with a DC₅₀ of 23 nM. PROTAC CDK9 degrader-12 induces proteasome-dependent degradation of CDK9, blocks CDK9-mediated HIV-1 transcriptional elongation, and reduces HIV-1 RNA synthesis. PROTAC CDK9 degrader-12 is applicable to research related to HIV-1 infection.
(Pink: CDK9 ligand (HY-181275); Blue: VHL ligand (HY-120217); Black: linker).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3052648-82-2
Fòrmula: C₆₀H₈₂N₁₄O₇S₂
Peso molecular:1175.51

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PROTAC CDK9 degrader-12 Chemical Structure

No. CAS: 3052648-82-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
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Actividad biológica

Descripciòn

PROTAC CDK9 degrader-12 is a selective CDK9 PROTAC degrader with a DC₅₀ of 23 nM. PROTAC CDK9 degrader-12 induces proteasome-dependent degradation of CDK9, blocks CDK9-mediated HIV-1 transcriptional elongation, and reduces HIV-1 RNA synthesis. PROTAC CDK9 degrader-12 is applicable to research related to HIV-1 infection^[1]. (Pink: CDK9 ligand (HY-181275); Blue: VHL ligand (HY-120217); Black: linker).

IC₅₀ & Target^[1]

CDK9

23 nM ()

VHL

Ver todos los productos específicos de isoformas PROTACs :

Ver todos los productos específicos de isoformas CDK :

Ver todos los productos específicos de isoformas HIV :

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

In Vitro

PROTAC CDK9 degrader-12 (1.0 μM, unspecified serial dilutions; variable times) potently inhibits HIV-1 replication in SupT1 cells (IC₅₀ = 78.92 nM) with a high selectivity index (531), acting by blocking CDK9-mediated HIV-1 transcription elongation, and its anti-HIV-1 activity is dependent on wild-type CDK9 degradation^[1].
PROTAC CDK9 degrader-12 (10 μM; 24 h) exhibits no obvious cytotoxicity in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3052648-82-2
Peso molecular 1175.51
Fòrmula C₆₀H₈₂N₁₄O₇S₂
SMILES

CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCCCCCCN4N=NC(CN5CCN(S(=O)(C6=CC=C(NC7=NC8=C(C=N7)C=C(C(N(C)C)=O)N8C9CCCC9)C=C6)=O)CC5)=C4)=O)C(C)(C)C)=O)=O)C=C2)SC=N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang B, et al. A potent and selective PROTAC degrader of CDK9 as effective inhibitor of HIV-1 RNA synthesis. Mol Divers. Published online November 12, 2025. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

PROTAC CDK9 degrader-12

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PROTAC CDK9 degrader-12

Ver todos los productos específicos de isoformas PROTACs

Ver todos los productos específicos de isoformas CDK

Ver todos los productos específicos de isoformas HIV

Ver todos los productos específicos de isoformas DNA/RNA Synthesis

Actividad biológica

Chemical Information

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Referencias

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PROTAC CDK9 degrader-12 Related Classifications

HY-181231 Related Classifications