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Referencia número: HY-183620

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PSB-24379

PSB-24379 is a CD39 inhibitor that potently inhibits human membrane-bound CD39 (K_i = 77.4 nM) and truncated soluble human CD39 (K_i = 23.1 nM). PSB-24379 reduces the level of ATP hydrolysis in melanoma and breast cancer cell membranes. PSB-24379 partially reverses ATP-mediated suppression of T cell activation and proliferation in a high-ATP environment. PSB-24379 can be used in research related to melanoma and breast cancer.

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Fòrmula: C₃₀H₃₂N₅O₇PS
Peso molecular:637.64

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Please store the product under the recommended conditions in the Certificate of Analysis.

PSB-24379 Chemical Structure

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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Descripciòn

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In Vitro

PSB-24379 potently inhibits both human membrane-bound CD39 (Ki = 77.4 nM) and truncated soluble human CD39 (Ki = 23.1 nM)^[1].
PSB-24379 inhibits human CD73 with a K_i of 240 nM^[1].
PSB-24379 reduces ATP hydrolysis activity in membrane preparations from human Ma-Mel-65 melanoma cells and human MDA-MB-231 triple-negative breast cancer cells^[1].
PSB-24379 partially reverts ATP-mediated suppression of T cell activation in primary human peripheral blood mononuclear cells in an ATP-rich environment^[1].
PSB-24379 exhibits high metabolic stability in human and mouse liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 637.64
Fòrmula C₃₀H₃₂N₅O₇PS
SMILES

O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCCCCC4=CC=CC=C4)=C3N=C2SC5=C(C=CC=C6)C6=CC=C5)O[C@@H]1COP(O)(O)=O
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Bi C, et al. Nucleotide-Derived Competitive Inhibitors of Ectonucleotidase CD39─A Promising Extracellular Target for Immunotherapy of Cancer. J Med Chem. 2026;69(9):10828-10864. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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PSB-24379

Ver todos los productos específicos de isoformas NTPDase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PSB-24379 Related Classifications

HY-183620 Related Classifications