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Referencia número: HY-12730

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RG7109

RG7109 is a non-nucleoside allosteric inhibitor of the hepatitis C virus NS5B polymerase. RG7109 inhibits HCV replication in replicon assays.

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No. CAS: 1257830-82-2
Fòrmula: C₂₇H₂₉N₃O₅S
Peso molecular:507.60

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

RG7109 Chemical Structure

No. CAS: 1257830-82-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

RG7109 is a non-nucleoside allosteric inhibitor of the hepatitis C virus NS5B polymerase. RG7109 inhibits HCV replication in replicon assays^[1]^[2].

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In Vitro

Viral Infection

RG7109 is a potent, equipotent inhibitor of GT-1a H77 and GT-1b Con1 HCV replicons, maintaining potency of ≤10 nM in 40% serum, with serum shifts of 3.8- to 9.4-fold^[1].
RG7109 retains potency against GT-1a and GT-1b NS5B isolates in transient replicon assays, with the greatest reduction in potency observed against the RO-38 isolate containing S556G^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1257830-82-2
Peso molecular 507.60
Fòrmula C₂₇H₂₉N₃O₅S
SMILES

CS(=O)(NC1=CC=C(C2=CC3=C(OC)C(C(C)(C)C)=CC(C4=CC=C(OC)NC4=O)=C3N=C2)C=C1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Talamas FX, et al. Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. Journal of medicinal chemistry. 2014 Mar 13;57(5):1914-31. [Content Brief]

[2]. de la Guardia C, et al. Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2. Molecules (Basel, Switzerland). 2018 Mar 16;23(3):672.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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