S-1255
S-1255 is an orally active and highly selective endothelin ETA receptor antagonist (Kd=0.39 nM). S-1255 blocks vasoconstriction and sustains hypotensive effects in hypertensive rats. S-1255 is promising for research of hypertension and cardiovascular disorders.
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- No. CAS: 203918-14-3
- Fòrmula: C27H24O7
- Peso molecular:460.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
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ETA |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| COS-7 | IC50 |
120 nM
Compound: 48(R)
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Binding affinity to endothelin B receptor measured by inhibition of [125I]ET-3 binding recombinant pig ET-B receptor expressed in COS-7 cells
Binding affinity to endothelin B receptor measured by inhibition of [125I]ET-3 binding recombinant pig ET-B receptor expressed in COS-7 cells
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[PMID: 11985472] |
Chemical Information
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No. CAS 203918-14-3
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Peso molecular 460.48
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Fòrmula C27H24O7
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SMILES
OC(C1=C(C2=CC=C(C=C2)OC)C3=CC(OC(C)C)=CC=C3O[C@@H]1C4=CC=C(OCO5)C5=C4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
S-1255 Related Classifications
HY-13711 Related Classifications
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