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Referencia número: HY-149300

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SB-1436

SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC₅₀s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with K_is of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2925298-08-2
Fòrmula: C₂₅H₂₁ClFNO
Peso molecular:405.89

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SB-1436 Chemical Structure

No. CAS: 2925298-08-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

EeAChE

0.176 μM (IC₅₀)

eqBCHE

0.37 μM (IC₅₀)

EeAChE

0.046 μM (Ki)

eqBCHE

0.115 μM (Ki)

Ver todos los productos específicos de isoformas Cholinesterase (ChE) :

AChE
BChE

In Vitro

SB-1436 (Compound 7av) (1 μM, 20 min) inhibits AChE, BChE and rHuAChE with IC₅₀s of 0.176, 0.37 and 0.08 μM, respectively^[1].
SB-1436 (0.78-100 μM, 48 hours) reduces the cell viability in J774A.1 and primary astrocytes cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

J774A.1 cells and primary astrocytes
Concentration:

0.78-100 μM
Incubation Time:

48 hours
Result:

Reduced the cell viability in J774A.1 and primary astrocytes cell lines, and its GI₅₀ in both cell types is ∼6.25 μM.

Chemical Information

No. CAS 2925298-08-2
Peso molecular 405.89
Fòrmula C₂₅H₂₁ClFNO
SMILES

COC1=CC2=C(C=C(/C=C/C3=CC=[N+](CC4=CC=C(F)C=C4)C=C3)C=C2)C=C1.[Cl-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8(20):17591-17608. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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SB-1436

Ver todos los productos específicos de isoformas Cholinesterase (ChE)

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SB-1436 Related Classifications

HY-149300 Related Classifications