Sulbenicillin disodium
Based on 1 Customer Validation
Sulbenicillin disodium is a semisynthetic α-sulfonylbenzylpenicillin antibiotic. Sulbenicillin disodium exerts antibacterial activity against multiple gram-negative rods. Sulbenicillin disodium inhibits primary and secondary platelet aggregation, serotonin release from platelets, and platelet adherence via platelet surface coating. Sulbenicillin disodium can be used for the research of Pseudomonas aeruginosa, Pseudomonas maltophilia, and Pseudomonas cepacia infections.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.84%
- No. CAS: 28002-18-8
- Fòrmula: C16H16N2Na2O7S2
- Peso molecular:458.42
-
Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Antibiotic
More
Actividad biológica
Descripciòn
IC50 & Target
|
β-lactam |
In Vitro
Sulbenicillin disodium (50-200 μg/mL) binds to human albumin in vitro with an approximate 70% bound fraction in the clinically relevant concentration range of 50 to 200 μg/mL[1].
Sulbenicillin disodium demonstrates in vitro antibacterial activity against clinical isolates of Proteus mirabilis (95% of strains have MIC50 ≤6 μg/mL) and Pseudomonas aeruginosa (90% of strains have MIC50 <20 μg/mL)[1].
Sulbenicillin disodium (0.2-25 mM) inhibits ADP-, epinephrine-, and collagen-induced aggregation of human platelets in vitro, with a minimum effective concentration of 5 mM for inhibiting secondary ADP-induced aggregation and collagen-induced maximal aggregability[3].
Sulbenicillin disodium (5-25 mM) inhibits [14C]-serotonin release from human platelets in vitro at 25 mM, with minimal effect at 5 mM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 28002-18-8
-
Appearance Solid
-
Peso molecular 458.42
-
Fòrmula C16H16N2Na2O7S2
-
Color White to off-white
-
SMILES
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C(C3=CC=CC=C3)S(=O)(O[Na])=O)=O)N1C2=O)O[Na]
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
In Vitro:
H2O : 250 mg/mL (545.35 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (218.14 mM); Clear solution; Need ultrasonic
Pureza y Documentación
-
Ficha de datos (278 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Hansen IB, et al. Pharmacokinetics of sulbenicillin, a new broad-spectrum semisynthetic penicillin. Clin Pharmacol Ther. 1975;17(3):339-347. [Content Brief]
[2]. Tsuchiya K, et al. Comparative in vitro activities of SCE-129, sulbenicillin, gentamicin, and dibekacin against Pseudomonas. Antimicrob Agents Chemother. 1978;13(3):536-539. [Content Brief]
[3]. Ikeda Y, et al. Inhibition of platelet function by sulbenicillin and its metabolite. Antimicrob Agents Chemother. 1978;13(5):881-883. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.1814 mL | 10.9070 mL | 21.8141 mL | 54.5351 mL |
| 5 mM | 0.4363 mL | 2.1814 mL | 4.3628 mL | 10.9070 mL | |
| 10 mM | 0.2181 mL | 1.0907 mL | 2.1814 mL | 5.4535 mL | |
| 15 mM | 0.1454 mL | 0.7271 mL | 1.4543 mL | 3.6357 mL | |
| 20 mM | 0.1091 mL | 0.5454 mL | 1.0907 mL | 2.7268 mL | |
| 25 mM | 0.0873 mL | 0.4363 mL | 0.8726 mL | 2.1814 mL | |
| 30 mM | 0.0727 mL | 0.3636 mL | 0.7271 mL | 1.8178 mL | |
| 40 mM | 0.0545 mL | 0.2727 mL | 0.5454 mL | 1.3634 mL | |
| 50 mM | 0.0436 mL | 0.2181 mL | 0.4363 mL | 1.0907 mL | |
| 60 mM | 0.0364 mL | 0.1818 mL | 0.3636 mL | 0.9089 mL | |
| 80 mM | 0.0273 mL | 0.1363 mL | 0.2727 mL | 0.6817 mL | |
| 100 mM | 0.0218 mL | 0.1091 mL | 0.2181 mL | 0.5454 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sulbenicillin disodium Related Classifications
HY-N7097 Related Classifications
Powered by Bioz