TBZ-1
TBZ-1 is a cell-permeable fluorescent probe that monitors immunoproteasome (Proteasome) (iCP) activity in cells. TBZ-1 is useful for lung cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2357123-44-3
- Fòrmula: C68H90N14O15S
- Peso molecular:1375.59
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
TBZ-1 reports β5i/iCP activity in IFN-γ-treated A549 cells, and this activity is attenuated by iCP inhibition[1].
TBZ-1 is approximately 35% cell-permeable in the live-cell assay[2].
TBZ-1 (31 μM) produces intracellular Rh110 fluorescence in IFN-γ-treated A549 cells that increases over 0-30 min and is reduced by iCP inhibition[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2357123-44-3
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Peso molecular 1375.59
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Fòrmula C68H90N14O15S
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Muli CS, et al. Immunoproteasome as a Target for Prodrugs. J Med Chem. 2025 Mar 27;68(6):6507-6517. [Content Brief]
[2]. Zerfas BL, et al. Monitoring the Immunoproteasome in Live Cells Using an Activity-Based Peptide-Peptoid Hybrid Probe. Journal of the American Chemical Society. 2019 Apr 03;141(13):5252-5260. [Content Brief]
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Topics Immunoproteasome & Neurodegenerative Diseases
The immunoproteasome is a specialized form of the proteasome that is induced by inflammatory cytokines and cellular stress and contributes to antigen processing, protein quality control, and degradation of oxidatively damaged proteins.
2026-06-18
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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