THPN
Based on 1 Customer Validation
THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.00%
- No. CAS: 100079-26-3
- Fòrmula: C15H22O4
- Peso molecular:266.33
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas Nuclear Hormone Receptor 4A/NR4A
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Actividad biológica
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Nur77/NR4A1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
43 μM
Compound: 8
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Cytotoxicity against human CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
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[PMID: 18295493] |
| CCRF-CEM | IC50 |
50 μM
Compound: 8
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Cytotoxicity against human CEM cells after 24 hrs by MTT assay
Cytotoxicity against human CEM cells after 24 hrs by MTT assay
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[PMID: 18295493] |
| L1210 | IC50 |
22 μM
Compound: 8
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Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay
Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay
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[PMID: 18295493] |
| L1210 | IC50 |
22 μM
Compound: 8
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Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay
Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay
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[PMID: 18295493] |
| Vero | IC50 |
>1 μM
Compound: 8
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Cytotoxicity against african green monkey VERO cells
Cytotoxicity against african green monkey VERO cells
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[PMID: 18295493] |
| Vero | IC50 |
>299 μM
Compound: 8
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Genotoxicity against african green monkey VERO cells
Genotoxicity against african green monkey VERO cells
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[PMID: 18295493] |
Chemical Information
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No. CAS 100079-26-3
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Appearance Solid
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Peso molecular 266.33
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Fòrmula C15H22O4
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Color White to off-white
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SMILES
CCCCCCCCC(C1=CC(O)=C(O)C(O)=C1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (265 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Wei-jia Wang, et al. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol. 2014 Feb;10(2):133-40. [Content Brief]
[2]. Li Li, et al. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat Chem Biol. 2015 May;11(5):339-46. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
THPN Related Classifications
HY-113827 Related Classifications
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